AI Article Synopsis
- The study examined how different doses of phencyclidine affect levels of dopamine (DA), DOPAC, and HVA in the brains of both anesthetized and awake rats using advanced techniques.
- At a dose of 20 mg/kg, phencyclidine significantly increased DA levels, while 10 mg/kg caused no change and 1 mg/kg decreased DA levels slowly.
- In conscious rats, higher doses resulted in reduced levels of DOPAC and HVA, suggesting complex interactions affecting DA synthesis and release based on the dosage.
Article Abstract
Dose-dependent effects of phencyclidine on extracellular levels of dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the neostriatum were studied in both urethane-anesthetized and conscious rats. In vivo microdialysis was used to collect 10 min samples that were analyzed for levels of DA, DOPAC and HVA, using high-performance liquid chromatography with electrochemical detection (HPLC-EC). In both the anesthetized and conscious preparations, 20 mg/kg of phencyclidine produced an increase in extracellular levels of DA, 10 mg/kg resulted in no change, while 1 mg/kg produced a slow decrease. In the anesthetized animals phencyclidine did not have a significant effect on levels of DOPAC or HVA, but in the conscious animals phencyclidine produced a dose-dependent decrease in levels of DOPAC and HVA. The increase in levels of DA could be the result of increased release of DA or inhibition of the uptake of DA. The decrease in levels of DOPAC and HVA, at the 1 mg/kg dose, could result from a decrease in the synthesis of DA that is offset at the 10 and 20 mg/kg doses by opposing mechanisms.
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| http://dx.doi.org/10.1016/0028-3908(90)90089-a | DOI Listing |
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