AI Article Synopsis
- The asymmetric synthesis of 3-indolylglycine derivatives was successfully performed using an oxidative heterocoupling reaction, focusing on the selective functionalization of unprotected indoles.
- This process utilized a chiral nucleophilic glycine nickel(II) complex to create adducts with significant diastereoselectivity.
- The resulting adducts decomposed easily, leading to high-yield production of 3-indolylglycine derivatives.
Article Abstract
The asymmetric synthesis of 3-indolylglycine derivatives was achieved by an oxidative heterocoupling reaction. This method for the selective C-3 functionalization of unprotected indoles with the chiral equivalent of a nucleophilic glycine nickel(II) complex afforded adducts with high diastereoselectivities. The decomposition of adducts readily afforded 3-indolylglycine derivatives in high yields.
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| http://dx.doi.org/10.1039/c3cc38908a | DOI Listing |
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