AI Article Synopsis
- * A new, straightforward method was developed to modify these nanoparticles in a single reaction, using various dopamine derivatives to create multiple reactive sites on their surfaces.
- * The resulting MF-MPs maintain similar magnetic properties and size (around 25 nm) while allowing further functionalization through different chemical reactions, enabling the addition of specific molecules like ferrocene, horseradish peroxidase, and mannose.
Article Abstract
The synthesis of multifunctional magnetic nanoparticles (MF-MPs) is one of the most active research areas in advanced materials as their multifunctional surfaces allow conjugation of biological and chemical molecules, thus making it possible to achieve target-specific diagnostic in parallel to therapeutics. We report here a simple strategy to integrate in a one-step reaction several reactive sites onto the particles. The preparation of MF-MPs is based on their simultaneous modification with differently functionalized dopamine derivatives using simple solution chemistry. The formed MF-MPs show comparable magnetic properties to those of naked nanoparticles with almost unaltered particle size of around 25 nm. The different termini, amine, azide and maleimide functions, enable further functionalization of MF-MPs by the grafting-on approach. Michael addition, Cu(i) catalyzed « click » chemistry and amidation reactions are performed on the MF-MPs integrating subsequently 6-(ferrocenyl)-hexanethiol, horseradish peroxidase (HRP) and mannose.
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| http://dx.doi.org/10.1039/c3nr33506b | DOI Listing |
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