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http://dx.doi.org/10.1111/add.12096 | DOI Listing |
Int J Technol Assess Health Care
December 2024
Institute for Quality and Efficiency in Healthcare, Cologne, Germany.
Health Technology Assessment (HTA) in Europe has undergone significant evolution, culminating in the adoption of Regulation (EU) 2021/2282 on HTA (HTAR) aimed at fostering sustainable collaboration in HTA at the European Union (EU) level. The EUnetHTA 21 project, a 2-year initiative, was commissioned to address key methodological issues and prepare for the implementation of the HTAR. This commentary documents the outcomes of the EUnetHTA 21 project, focusing on Joint Clinical Assessments (JCAs), while analyzing challenges encountered and lessons learned for future collaboration under the HTAR.
View Article and Find Full Text PDFHum Reprod
October 2024
Department of Obstetrics and Gynecology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Clin Cancer Res
August 2024
Erasmus MC Cancer Institute, Erasmus University Medical Centre, Rotterdam, the Netherlands.
Purpose: Amid the need for new approaches to improve survival in pancreatic ductal adenocarcinoma (PDAC), immune-based therapies have garnered interest. Rintatolimod, a Toll-like receptor 3 (TLR-3) agonist, is a potential candidate due to its dual impact on restraining PDAC cell functions and boosting the antitumor immune response. This study investigates the effect of TLR-3 activation through rintatolimod on the peripheral immune landscape of patients with advanced PDAC.
View Article and Find Full Text PDFEur J Paediatr Neurol
July 2023
Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Amalia Children's Hospital, Department of Paediatric Neurology, Nijmegen, the Netherlands.
Signal Transduct Target Ther
November 2022
Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University, Munich, Germany.
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