AI Article Synopsis
- A variant in the Syntaxin 6 gene (rs1411478) has been linked to progressive supranuclear palsy (PSP), but this study investigates its role in Parkinson's disease (PD).
- The research involved analyzing STX6 genetic variability in PD patients from diverse regions like Canada, Norway, Taiwan, and Tunisia, as well as looking for harmful mutations in families.
- The study found no pathogenic mutations in STX6 and did not find significant differences in the genetic profiles between PD patients and controls, suggesting that STX6 is not involved in PD susceptibility.
Article Abstract
A variant in Syntaxin 6 (a soluble N-ethylmaleimide-sensitive factor attachment protein receptor STX6) (rs1411478) has been shown to be associated with progressive supranuclear palsy (PSP). Although Parkinson's disease (PD) and PSP are distinct neurodegenerative diseases, they share some clinical and genetic features. In this study, we evaluated STX6 genetic variability in PD susceptibility in ethnically matched case-control series from Canada, Norway, Taiwan and Tunisia and we evaluated the presence of pathogenic mutations within families. No pathogenic mutations were found in STX6. Similarly, statistical analysis of rs1411478 failed to identify differences in genotype or allelic frequencies between cases and controls. Our results do not support a role for STX6 in PD.
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| http://dx.doi.org/10.1016/j.parkreldis.2013.01.019 | DOI Listing |
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