Background: Prostate cancer is a serious public health problem that affects quality of life and has a significant mortality rate. The aim of the present study was to quantify the fractal dimension and Shannon's entropy in the histological diagnosis of prostate cancer.
Methods: Thirty-four patients with prostate cancer aged 50 to 75 years having been submitted to radical prostatectomy participated in the study. Histological slides of normal (N), hyperplastic (H) and tumor (T) areas of the prostate were digitally photographed with three different magnifications (40x, 100x and 400x) and analyzed. The fractal dimension (FD), Shannon's entropy (SE) and number of cell nuclei (NCN) in these areas were compared.
Results: FD analysis demonstrated the following significant differences between groups: T vs. N and H vs. N groups (p < 0.05) at a magnification of 40x; T vs. N (p < 0.01) at 100x and H vs. N (p < 0.01) at 400x. SE analysis revealed the following significant differences groups: T vs. H and T vs. N (p < 0.05) at 100x; and T vs. H and T vs. N (p < 0.001) at 400x. NCN analysis demonstrated the following significant differences between groups: T vs. H and T vs. N (p < 0.05) at 40x; T vs. H and T vs. N (p < 0.0001) at 100x; and T vs. H and T vs. N (p < 0.01) at 400x.
Conclusions: The quantification of the FD and SE, together with the number of cell nuclei, has potential clinical applications in the histological diagnosis of prostate cancer.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583746 | PMC |
| http://dx.doi.org/10.1186/1472-6890-13-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Investigation of the Effect of Periodontitis on Trabecular Bone Structure by Fractal Analysis.
Cureus
January 2025
Oral and Maxillofacial Radiology, Biruni University, İstanbul, TUR.
Objective: This study aimed to evaluate the trabecular microarchitecture in the interdental region of panoramic radiographs from periodontally healthy individuals and those with stage III/IV periodontitis using fractal analysis (FA), while also assessing the relationship between clinical periodontal parameters and FA outcomes.
Study Design: Clinical and radiographic records of 20 periodontally healthy individuals and 19 individuals with stage III/IV periodontitis were included. Clinical measurements including the plaque score, bleeding on probing, probing pocket depth, and clinical attachment level were recorded.
Retinal vascular geometry and its association to silent brain infarction.
BMC Ophthalmol
January 2025
Department of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Objective: To examine the relationship between retinal vascular geometry and silent brain infarction (SBI) in the Chinese population.
Methods: We conducted a cross-sectional study that retrospectively analyzed the fundus photographs, MRI and other clinical data of 227 SBIs and 227 controls who visited Shanghai Health And Medical Center for physical examination. The retinal vessel fractal dimension (FD), retinal artery fractal dimension (FDa), retinal vein fractal dimension (FDv), central retinal artery diameter in the region from 0.
Machine Learning Analysis of Glutamate Receptor Activity in Developing Locus Coeruleus Neurons.
Int J Neurosci
January 2025
Department of Mathematics, Payame Noor University, Tehran, Iran.
The developing brain undergoes a remarkable process of synapse production and maturation, particularly in glutamatergic synapses. In this study, we focused on the locus coeruleus (LC) nucleus, a brain region crucial for cognitive functions, to investigate the developmental changes in glutamatergic synaptic connections. Using the whole-cell patch clamp method, we recorded evoked excitatory postsynaptic currents (eEPSCs) from LC neurons in rats at ages 7, 14, and 21 days.
View Article and Find Full Text PDFOn the structure of nanoparticle clusters: effects of long-range interactions.
Phys Chem Chem Phys
January 2025
Department of Chemical Engineering, Delft University of Technology, Van der Maasweg 9, Delft, 2629HZ, The Netherlands.
The fractal structure of aggregates consisting of primary nanoparticles naturally arises during their synthesis. While typically considered to be a fully stochastic process, we suspect long-range interactions, in particular van der Waals forces, to induce an active pull on particles, altering the clustering process. Using an off-grid 3D model, we show that an active pull decreases the density and fractal dimension of formed clusters.
View Article and Find Full Text PDFCommunicating the interdependence of human, animal, and environmental health on X (formerly Twitter): Insights from the one health approach.
iScience
January 2025
Department of Biology and Geology, Universidad de Almería, La Cañada de San Urbano, 04120 Almería, Spain.
The COVID-19 pandemic has underscored societies' need for education and preparedness in addressing global environmental and health crises. Raising public awareness of the interdependence of human, animal, and environmental health is essential to engaging the public in environmental conservation and disease prevention. The One Health approach offers a holistic and multidisciplinary view for tackling challenges related to environmental and health issues by emphasizing the interplay of these three interconnected health dimensions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!