Background: The available drugs for diabetes, Insulin or Oral hypoglycemic agents have one or more side effects. Search for new antidiabetic drugs with minimal or no side effects from medicinal plants is a challenge according to WHO recommendations. In this aspect, the present study was undertaken to evaluate the antihyperglycemic and antihyperlipidemic effects of Piper longum root aqueous extract (PlrAqe) in streptozotocin (STZ) induced diabetic rats.
Methods: Diabetes was induced in male Wister albino rats by intraperitoneal administration of STZ (50 mg/kg.b.w). Fasting blood glucose (FBG) levels were measured by glucose-oxidase & peroxidase reactive strips. Serum biochemical parameters such as glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglycerides (TG), very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL) cholesterol were estimated. The activities of liver and kidney functional markers were measured. The statistical analysis of results was carried out using Student t-test and one-way analysis (ANOVA) followed by DMRT.
Results: During the short term study the aqueous extract at a dosage of 200 mg/kg.b.w was found to possess significant antidiabetic activity after 6 h of the treatment. The administration of aqueous extract at the same dose for 30 days in STZ induced diabetic rats resulted in a significant decrease in FBG levels with the corrections of diabetic dyslipidemia compared to untreated diabetic rats. There was a significant decrease in the activities of liver and renal functional markers in diabetic treated rats compared to untreated diabetic rats indicating the protective role of the aqueous extract against liver and kidney damage and its non-toxic property.
Conclusions: From the above results it is concluded that the plant extract is capable of managing hyperglycemia and complications of diabetes in STZ induced diabetic rats. Hence this plant may be considered as one of the potential sources for the isolation of new oral anti hypoglycemic agent(s).
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583796 | PMC |
| http://dx.doi.org/10.1186/1472-6882-13-37 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Analysis and Identification of Polyphenols in Fragaria, Rubus, and Ribes Species by Nontargeted UHPLC-PDA-MS Metabolite Profiling.
Methods Mol Biol
January 2025
Environmental and Biochemical Sciences, James Hutton Institute, Dundee, Scotland, UK.
Profiling of secondary metabolites within Fragaria sp. (strawberry), Rubus sp. (raspberries and blackberries), and Ribes sp.
View Article and Find Full Text PDFA comparative study of ionic pesticide sorption and degradation in contrasting Brazilian soils and the development of a novel 3-Phase Assay to assess sorption reversibility.
Environ Monit Assess
January 2025
Syngenta Ltd, Jealott's Hill International Research Centre, Warfield, Bracknell, RG42 6EY, UK.
Brazilian soils have distinctive characteristics to European and North American soils which are typically used to investigate pesticide fate. This study aimed to compare soil-water partition coefficient (K), reversibility of adsorption and degradation half-life (DT) of 5 pesticides covering a wide range of physico-chemical properties in contrasting Brazilian soils (Argissolo, Gleissolo, Latossolo and Neossolo) and a temperate (UK) alfisol soil, and to study their relationship with soil OM, clay and expandable clay content, CEC and pH. In addition, we used a novel laboratory test to evaluate sorption reversibility, the 3-Phase Assay (3PA).
View Article and Find Full Text PDFAchieving the smallest crystallite/particle size of zinc oxide nanoparticles (ZnO NPs) reported to date, measuring 5.2/12.41 nm with () leaf extract, this study introduces a facile green synthesis.
View Article and Find Full Text PDFAqueous extract of Atractylodes macrocephala Koidz. improves dexamethasone-induced skeletal muscle atrophy in mice by enhancing mitochondrial biological function.
Exp Gerontol
January 2025
School of Food and Bioengineering, Xihua University, Chengdu 610039, China.
Purpose: The study aims to investigate the therapeutic effects of the aqueous extract of Atractylodes macrocephala Koidz. (AEA) on dexamethasone (Dex) -induced sarcopenia in mice and to explore its possible mechanisms of action.
Methods: This study utilized bioinformatics analysis to explore the primary pathogenic mechanisms of age-related sarcopenia and Dex-induced muscle atrophy.
Deep eutectic solvent-enabled lignocellulosic biomass valorization: Toward understanding of biomass pretreatment, lignin dissolution, and lignin's antioxidant activity.
Int J Biol Macromol
January 2025
State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, No. 15 East Road of North Third Ring Road, Chao Yang District, Beijing 100029, China. Electronic address:
A comprehensive study was conducted to determine the effects of water and ethylene glycol (EG) on biomass pretreatment using a binary deep eutectic solvent (DES) containing choline chloride and acetic acid (1ChCl3AC) at a mole ratio of 1:3. Different quantities of water and EG were combined with 1ChCl3AC to pretreat wheat straw, miscanthus, eucalyptus, and sorghum stalk at 130 °C for 6 h. The changes in nanopore structure and surface roughness of wet biomass, as well as biomass crystallinity after 1ChCl3AC-based pretreatment were investigated using XRD and small-angle neutron scattering (SANS).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!