AI Article Synopsis
- Antimicrobial proteins (AMPs) are crucial for higher eukaryotes as they defend against pathogens and help lower eukaryotes and prokaryotes compete for nutrients.
- AMPs vary widely in their structure, function, and mechanisms, indicating their diverse roles in nature.
- This review highlights small, cationic, cysteine-rich AMPs, focusing on their antifungal properties and other biological functions that could be utilized in medicine, agriculture, and biotechnology.
Article Abstract
Antimicrobial proteins (AMPs) are widely distributed in nature. In higher eukaryotes, AMPs provide the host with an important defence mechanism against invading pathogens. AMPs of lower eukaryotes and prokaryotes may support successful competition for nutrients with other microorganisms of the same ecological niche. AMPs show a vast variety in structure, function, antimicrobial spectrum and mechanism of action. Most interestingly, there is growing evidence that AMPs also fulfil important biological functions other than antimicrobial activity. The present review focuses on the mechanistic function of small, cationic, cysteine-rich AMPs of mammals, insects, plants and fungi with antifungal activity and specifically aims at summarizing current knowledge concerning additional biological properties which opens novel aspects for their future use in medicine, agriculture and biotechnology.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569713 | PMC |
| http://dx.doi.org/10.1016/j.fbr.2012.07.002 | DOI Listing |
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