Metal-on-metal (MOM) bearing surfaces in total hip arthroplasty have been recently shown to have acceptable survivorship properties, and they have certain advantages and disadvantages when compared to conventional metal-on-polyethylene bearing surfaces. Like traditional metal-on-polyethylene bearings, these metal-on-metal implants may also suffer from catastrophic failure. Patients can develop a local reaction to the metal ions produced by the articulation and present with pain or early loosening due to the local inflammatory reaction. The possible effects of MOM wear debris and its corrosion products are still the subject of debate. This case report represents an unusual situation in a 63-year-old woman in which extensive lysis derived in massive femoral osteolysis and hip arthroplasty catastrophic failure.
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http://dx.doi.org/10.1007/s00590-012-1088-7 | DOI Listing |
Sensors (Basel)
December 2024
School of Mechatronic Engineering, Xi'an Technology University, No.2 Xuefuzhonglu Road, Weiyang District, Xi'an 710021, China.
Aero-engines, particularly turbofan engines, are highly complex systems that play a critical role in the aviation industry. As core components of modern aircraft, they provide the thrust necessary for flight and are essential for safe and efficient operations. However, the complexity and interconnected nature of these engines also make them vulnerable to failures and, in the context of intelligent systems, potential cyber-attacks.
View Article and Find Full Text PDFCureus
December 2024
Obstetrics, Orlando Regional Medical Center, Orlando, USA.
Cardiol Young
January 2025
The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Br J Haematol
January 2025
Division of Nephrology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
We describe a patient with sickle cell disease (SCD) and elevated antiphospholipid antibodies (aPL) who developed multi-organ failure resembling catastrophic antiphospholipid syndrome. Autoimmune screening revealed several autoantibodies characteristic of systemic lupus erythematosus (SLE). Notably, routinely housed and unmanipulated transgenic sickle mice displayed significantly elevated titres of aPL- and SLE-associated autoantibodies.
View Article and Find Full Text PDFEMBO J
January 2025
Newcastle University Biosciences Institute (NUBI), Central Parkway, Newcastle University, NE1 3BZ, Newcastle upon Tyne, UK.
The cellular concentrations of splicing factors (SFs) are critical for controlling alternative splicing. Most serine and arginine-enriched (SR) protein SFs regulate their own concentration via a homeostatic feedback mechanism that involves regulation of inclusion of non-coding 'poison exons' (PEs) that target transcripts for nonsense-mediated decay. The importance of SR protein PE splicing during animal development is largely unknown despite PE ultra-conservation across animal genomes.
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