AI Article Synopsis
- Three patients with myelodysplastic syndrome (MDS) displayed very low neutrophil alkaline phosphatase (NAP) activity, below a defined score of 10.
- All patients exhibited differences in neutrophil structure, specifically hypogranulation.
- After treatment with granulocyte colony-stimulating factor (G-CSF), NAP activity improved temporarily, but none of the patients had serious infections, indicating that NAP activity might not be crucial for neutrophil function.
Article Abstract
Three patients with myelodysplastic syndrome (MDS) had absent or extremely low levels of neutrophil alkaline phosphatase (NAP) activity (arbitrarily defined as an NAP score <10). All patients showed varying degrees of hypogranulation in neutrophil morphology. The NAP activity levels transiently normalized following the administration of granulocyte colony-stimulating factor (G-CSF) in two cases. No patients experienced any severe infectious episodes. These results suggest that NAP activity is not central to the neutrophil function.
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| http://dx.doi.org/10.2169/internalmedicine.52.9114 | DOI Listing |
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