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Hsp90aa1/JUN/Ccl2 regulatory axis mediates migration and differentiation of NSPCs, promoting the onset and progression of early post-ischemic stroke epilepsy.
Neurobiol Dis
October 2024
Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, China. Electronic address:
Early-onset epilepsy following ischemic stroke is a severe neurological condition, the pathogenesis of which remains incompletely understood. Recent studies suggest that Neural stem/progenitor cells (NSPCs) play a crucial role in the disease process, yet the precise molecular mechanisms regulating NSPCs have not been thoroughly investigated. This study utilized single-cell transcriptome sequencing and bioinformatics analysis to identify disease-related genes, which were subsequently validated in both in vitro and in vivo experiments.
View Article and Find Full Text PDFA Systematic Review on Outcomes of Patients with Heatstroke and Heat Exhaustion.
Open Access Emerg Med
September 2023
Department of Surgery, Umm AL-Qura University, Makkah, Saudi Arabia.
Introduction: Heatstroke (HS) is a severe form of heat-related illness (HRI) associated with high morbidity and mortality, representing a condition that includes long-term multiorgan dysfunction and susceptibility to further heat illness.
Methods: In a systematic review searching Medline PubMed from the studies conducted between 2009 and 2020, 16 papers were identified.
Results: A hallmark symptom of heat stroke is CNS dysfunction (a hallmark sign of HS) which manifests as mental status changes, including agitation, delirium, epilepsy, or coma at the time of the collapse.
Kainic Acid-Induced Excitotoxicity Leads to the Activation of Heat Shock Response.
Mol Neurobiol
November 2023
Department of Medical Biology, Faculty of Medicine, Aydin Adnan Menderes University, Aydin, Turkey.
Heat shock response (HSR) which is regulated by heat shock factor 1 (HSF1) is the most important mechanism and the major regulator that prevents protein aggregation in neurodegenerative diseases. Excitotoxicity, which is the accumulation of excess glutamate in synaptic cleft, is observed in age-dependent neurodegenerative diseases and also in stroke, epilepsy, and brain trauma. Only a few studies in the literature show the link between excitotoxicity and HSR.
View Article and Find Full Text PDFMolecular Chaperones and miRNAs in Epilepsy: Pathogenic Implications and Therapeutic Prospects.
Int J Mol Sci
August 2021
Department of Biomedicine, Neuroscience and Advanced Diagnostics, Section of Human Anatomy, University of Palermo, 90127 Palermo, Italy.
Article Synopsis
- * MicroRNAs (miRNAs) and the chaperone system (CS) are being studied as potential biomarkers and therapeutic targets due to their roles in seizure regulation and neuronal survival.
- * The findings in this review aim to identify specific molecular targets related to miRNAs and CS components, which could enhance understanding of epilepsy mechanisms and lead to better seizure prediction and treatment strategies.
[Exertional heat stroke in athletes and soldiers].
Ned Tijdschr Geneeskd
August 2020
Radboudumc, afd. Neurologie,Nijmegen.
Exertional heat stroke (EHS) is a medical emergency characterized by life-threatening hyperthermia and central nerve system dysfunction during or directly after exercise. Early recognition and aggressive cooling reduces morbidity and mortality of patients with EHS. Therefore, all health care professionals involved in acute care should immediately recognise EHS and start cooling with cold water immersion as soon as possible.
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