AI Article Synopsis
- β-Catenin is vital for various liver functions, but its specific role in acute liver failure is not well understood.
- Using knockout mice without β-Catenin in hepatocytes, researchers discovered that the loss reduced certain liver damage and cell death but worsened other types of liver injury.
- They found that β-Catenin helps balance injury signals by inhibiting NF-κB, which leads to less damage from one pathway (Fas) while increasing stress from another pathway (oxidative stress).
Article Abstract
β-Catenin plays many critical roles during various liver physiological and pathological processes. However, the role of β-Catenin in acute liver failure remains unclear. Using hepatocyte specific β-Catenin knockout mice, we found that loss of β-Catenin in hepatocyte significantly reduced GalN/LPS-induced liver damage and hepatocyte apoptosis, but exacerbated Jo2-mediated liver injury. Mechanistically, the dual effects of β-Catenin attributes on its function of inhibiting NF-κB signaling, which aggravates oxidative stress but decreases Fas expression under injury conditions. In conclusion, β-Catenin plays an important role in regulating the balance between TNF-α and Fas-induced liver injury via its effect on NF-κB.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.canlet.2013.02.008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!