The peptide hormone gastrin is an important factor for the maintenance and homeostasis of the gastric mucosa. We show that gastrin stimulates proliferation in a dose-dependent manner in the human gastric adenocarcinoma cell line AGS-GR. Furthermore, we demonstrate that the MAPK scaffold protein MEK partner 1 (MP1) is important for gastrin-induced phosphorylation of ERK1 and ERK2 and that MP1 promotes gastrin-induced proliferation of AGS-GR cells. Our results suggest a role of MP1 in gastrin-induced cellular responses involved in proliferation and homeostasis of the gastric mucosa.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611038 | PMC |
| http://dx.doi.org/10.1007/s11626-013-9588-2 | DOI Listing |
Publication Analysis
Top Keywords
gastrin-induced proliferation
8
mek partner
8
partner mp1
8
homeostasis gastric
8
gastric mucosa
8
mp1 gastrin-induced
8
gastrin-induced
4
proliferation involves
4
involves mek
4
mp1
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!