The alkynylation of β-C(sp(3))-H bonds in aliphatic amides with alkynyl halides has been enabled using Pd(0)/N-heterocyclic carbene (NHC) and Pd(0)/phosphine (PR3) catalysts. This is the first example of utilizing [AlkynylPd(II)L(n)] complexes to activate C(sp(3))-H bonds.
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| http://dx.doi.org/10.1021/ja400648w | DOI Listing |
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