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Association of agonal phase duration with heart utilization and post-transplant outcomes in donation after circulatory death heart transplantation.
J Heart Lung Transplant
November 2024
Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address:
Background: This study evaluates the impact of the agonal phase and related hemodynamic measures on post-transplant outcomes and heart utilization in donation after circulatory death (DCD) heart transplantation.
Methods: United Network for Organ Sharing registry was queried to analyze adult recipients who underwent isolated DCD heart transplantation between January 1, 2019 and September 30, 2023. The recipients were stratified into 2 groups based on donor agonal period: <30 and ≥30 minutes.
Sights and Sounds of Respiratory Changes During Hospice Death Vigils: Hospice Caregivers Experience.
J Pain Symptom Manage
November 2024
Division of Palliative Medicine (P.W.), Department of Medicine, Washington University in St. Louis, St Louis, Missouri.
Context: Research has documented common respiratory changes at the end of life for hospice patients. Some studies have noted these symptoms as distressing and challenging for families, and as a potential reason for emergency room visits and hospice benefit revocation. However, the experiences and emotions of family members regarding these respiratory changes in the final days, particularly when they are alone in a home setting, are not well documented.
View Article and Find Full Text PDFA Phase I trial of Non-invasive Ventilation and seizure prophylaxis with levetiracetam In Children with Cerebral Malaria Trial (NOVICE-M Trial).
Wellcome Open Res
May 2024
Institute of Clinical Trials & Methodology, Medical Research Council Clinical Trials Unit at University College London, London, England, WC1V 6J, UK.
Background: African children with cerebral malaria and seizures caused are at greater risk of poor outcomes including death and neurological sequelae. The agonal events are severe hypoventilation and respiratory arrest often triggered by seizures. We hypothesised that prophylactic anti-seizure medication (ASM) could avert 'spikes' of intracranial pressure during or following seizures and that adequate ventilation could be supported by biphasic Cuirass Ventilation (BCV) which requires no intubation.
View Article and Find Full Text PDFPostmortem clots (PMC) of the heart; is it merely an artifact or a predictor of cause of death?
Ceylon Med J
November 2022
Faculty of Medicine, Rajarata University of Sri Lanka.
Background: Post Mortem Clots (PMC) are considered as artifacts observed during forensic autopsies; hence, their medico legal importance has not been evaluated at length in the past. This study was designed with the intent of finding the association of age, gender, cause of death (COD) and postmortem interval (PI) with PMC formation.
Methods: Secondary data of all postmortems performed by the 1st author from June,2015 to June,2018 at Teaching Hospital Anuradhapura were extracted.
Impact of Extraction Time During Donation After Circulatory Death Organ Procurement on Kidney Function After Transplantation in The Netherlands.
Transplant Direct
November 2023
Division of Hepatopancreatobiliary and Transplant Surgery, Department of Surgery, Erasmus Medical Center Transplant Institute, Rotterdam, The Netherlands.
Background: In The Netherlands, 60% of deceased-donor kidney offers are after donation after circulatory death. Cold and warm ischemia times are known risk factors for delayed graft function (DGF) and inferior allograft survival. Extraction time is a relatively new ischemia time.
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