[Determination of persistent organic compounds in serum by using gas chromatography coupled with triple quadrupole mass spectrometry].

G Ital Med Lav Ergon

Laboratorio di Misure Ambientali e Tossicologiche, Fondazione Salvatore Maugeri, via Salvatore Maugeri 4, 27100 Pavia, Italy.

Published: April 2013

Polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCs) are lipophilic and persistent compounds that were widely used in industrial and consumer products for decades until the late 70s. Due to their persistence and bioaccumulation, they are globally spread in the environment and may still be found in all environmental and biological media. Some have been classified as xenoestrogens or endocrine disruptors. Some others are known to have adverse effects for human health, including cancer. With the objective of establishing reference values, a fast and reliable method, previously developed and validated using single quadrupole mass spectrometry, was properly modified in order to simultaneously detect 10 organochlorine pesticides and 15 PCBs by using triple quadrupole. Use of triple quadrupole mass spectrometry has further increased the reliability of the method, so that it is now possible to collect more significant data concerning general population, which is the first step before the assessment of occupational exposure levels.

Download full-text PDF

Source

Publication Analysis

Top Keywords

triple quadrupole
12
quadrupole mass
12
organochlorine pesticides
8
mass spectrometry
8
[determination persistent
4
persistent organic
4
organic compounds
4
compounds serum
4
serum gas
4
gas chromatography
4

Similar Publications

Xiao Jianzhong Granules (XJZG), a well-known traditional prescription with protective effects on the gastric mucosa, as documented in the Treatise on Typhoid and Miscellaneous Diseases. Clinical studies have proven that XJZG exhibits significant anti-colitis properties and effectively alleviates duodenal ulcers. However, despite its clinical popularity, comprehensive studies on its chemical composition and in vivo metabolism remain limited.

View Article and Find Full Text PDF

Comprehensive IC-ICP-MS analysis of polyphosphonates and their transformation products.

J Chromatogr A

March 2025

Institute of Inorganic and Analytical Chemistry, University of Münster, Münster, Germany. Electronic address:

Polyphosphonates (PPs) are increasingly used in detergents and as antiscalants in Europe, with an estimated 18,600 tons annually entering surface waters. Aminopolyphosphonates (APPs) can be readily transformed by environmental processes, contrary to previous beliefs about PP stability during wastewater treatment. Together with the identification of glyphosate as a minor transformation product (TP) of the widely used diethylenetriamine penta(methylenephosphonate) (DTPMP), this necessitates further detailed APP transformation studies.

View Article and Find Full Text PDF

Background: Elevated homocysteine (Hcy) is a pathogenic mechanism of adverse pregnancy outcomes and PM-induced cardiovascular diseases. We investigated the associations of fine particulate matter (PM) and chemical constituent exposures with maternal circulatory Hcy in early pregnancy.

Methods: Serum Hcy and 5-methyltetrahydrofolate in 324 women with pregnancy (162 normal early pregnancy [NEP] and 162 early pregnancy loss [EPL]) were measured by ultra-performance liquid chromatography-tandem triple quadrupole mass spectrometry.

View Article and Find Full Text PDF

Simultaneous quantification of four urinary biomarkers related to oxidative stress using UHPLC-QqQ-MS/MS.

J Chromatogr B Analyt Technol Biomed Life Sci

March 2025

SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing, China. Electronic address:

Oxidative stress biomarkers have been associated with both acute and chronic health outcomes. However, traditional methods analyze different biomarkers separately, resulting in complex sample preparation, high sample consumption, lengthy processing time, and limited comparability. In this study, we presented a newly developed and validated method for the simultaneous determination of oxidative stress from multiple perspectives (DNA, lipids, and antioxidants).

View Article and Find Full Text PDF

Development and validation of a UPLC-MS/MS method for almonertinib with its active metabolite HAS-719 and anlotinib in human plasma.

J Pharm Biomed Anal

February 2025

Department of Pharmacy, The First Affiliated Hospital of Soochow University, Suzhou, Jiang Su 215006, PR China; College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215006, PR China. Electronic address:

Almonertinib and anlotinib are tyrosine kinase inhibitors used to treat malignant tumors, with their combination currently applied to non-small cell lung cancer (NSCLC) patients. This study aimed to develop a simple and rapid UPLC-MS/MS method for simultaneously detecting almonertinib, its active metabolite HAS-719, and anlotinib in human plasma. The analytes were separated on a Waters HSST3-C18 column following protein precipitation with acetonitrile.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!