The impact of the brain's immune response to disease is no longer relegated to a secondary event of limited interest. Multiple types of brain and spinal cord injuries and diseases show varying immune phenotypes over the time course of the disease. The collection of articles illustrates the wide reach of brain immunity and provides research papers and reviews that illustrate this point. These articles have added both new information and new directions to consider, and I would like to thank all of the participants for their insightful contributions to the field.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652666 | PMC |
http://dx.doi.org/10.1007/s11481-013-9437-9 | DOI Listing |
Front Immunol
September 2024
Unidad de Medicina Experimental "Ruy Pérez Tamayo", Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Microglia are highly dynamic cells that have been mainly studied under pathological conditions. The present review discusses the possible implication of microglia as modulators of neuronal electrical responses in physiological conditions and hypothesizes how these cells might modulate hypothalamic circuits in health and during obesity. Microglial cells studied under physiological conditions are highly diverse, depending on the developmental stage and brain region.
View Article and Find Full Text PDFJ Neuroinflammation
April 2024
Center for Brain Immunology and Glia, University of Virginia, Charlottesville, VA, USA.
Microglia are sexually dimorphic, yet, this critical aspect is often overlooked in neuroscientific studies. Decades of research have revealed the dynamic nature of microglial-neuronal interactions, but seldom consider how this dynamism varies with microglial sex differences, leaving a significant gap in our knowledge. This study focuses on P2RY12, a highly expressed microglial signature gene that mediates microglial-neuronal interactions, we show that adult females have a significantly higher expression of the receptor than adult male microglia.
View Article and Find Full Text PDFiScience
April 2024
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Cerebral microbleeds (CMBs) are associated with higher risk for various neurological diseases including stroke, dementia, and Alzheimer's disease. However, the understanding of cellular pathology of CMBs, particularly in deep brain regions, remains limited. Utilizing two-photon microscopy and microprism implantation, we longitudinally imaged the impact of CMBs on neuronal and microglial activities across cortical depths in awake mice.
View Article and Find Full Text PDFMicroglia are sexually dimorphic, yet, this critical aspect is often overlooked in neuroscientific studies. Decades of research have revealed the dynamic nature of microglial-neuronal interactions, but seldom consider how this dynamism varies with microglial sex differences, leaving a significant gap in our knowledge. This study focuses on P2RY12, a highly expressed microglial signature gene that mediates microglial-neuronal interactions, we show that adult females have a significantly higher expression of the receptor than adult male microglia.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!