The objective of the present study was to identify chemical constituents of volatile oil from Pyrolae herba (PHVO) and evaluate the antiproliferative activity of PHVO against SW1353 human chondrosarcoma cells. The volatile oil from Pyrolae herba was prepared by hydrodistillation and characterized by gas chromatography-mass spectroscopy (GC-MS). A total of 12 components in PHVO were identified representing 81.62% of the total integrated chromatographic peaks. The major compounds were found to be n-hexadecanoic acid (29.29%), cedrol (17.08%), 6,10,14-trimethyl-2-pentadecanone (9.59%) and cis-9-octadecadienoic acid (8.23%). The antiproliferative activity of PHVO against SW1353 cells was investigated using MTT assay, flow cytometry and western blot analysis. Our results demonstrated that PHVO inhibited SW1353 cell viability in a dose- and time-dependent manner. Furthermore, PHVO treatment decreased the number of cells entering the S phase and caused a reduction in the expression of cyclin D1, cyclin-dependent kinase (CDK)4 and CDK6, whereas it caused an increase in the expression of p21. PHVO demonstrated potent antitumor activity against SW1353 cells, suggesting its potential use as a therapeutic agent in the treatment of chondrosarcoma.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3892/ijo.2013.1816 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Polyphenolic contents, antioxidant, and antimicrobial activities of Saccocalyx satureioides Coss. & Dur. essential oil and methanol extracts.
An Acad Bras Cienc
January 2025
University of M'sila, Department of Microbiology and Biochemistry, University Pole, Road Bordj Bou Arreridj, M'sila 28000, Algeria.
The whole plant Saccocalyx satureioides, an endemic medicinal plant in Algeria, was evaluated for its polyphenolic contents, antioxidant and antimicrobial activities. The polyphenolic contents of the plant methanolic extracts ranged from 170.47 to 285.
View Article and Find Full Text PDFEssential oil and aqueous extract of basil (Ocimum basilicum) in the diet of pacu (Piaractus mesopotamicus).
Braz J Biol
January 2025
Universidade Federal de Mato Grosso do Sul - UFMS, Faculdade de Medicina Veterinária e Zootecnia - FAMEZ, Campo Grande, MS, Brasil.
This study aimed to evaluate the effects of Ocimum basilicum supplementation in the diet for Piaractus mesopotamicus regarding productive performance, intestinal morphology, muscle residue, and hematological changes after simulated transport stress. Juvenile (23 g±0.08, n = 180) were stocked into 300-L tanks in three treatments and six replicates each: a control diet (not supplemented), a diet with 0.
View Article and Find Full Text PDFEvaluation of the antibacterial activity of essential oils from oregano (Origanum vulgare) against Escherichia coli strains isolated from meat products.
Braz J Biol
January 2025
Universidade Federal de Campina Grande - UFCG, Patos, PB, Brasil.
The objective of this study was to analyze the antimicrobial and anti-stick capacity of essential oil extracted from oregano (Origanum vulgare) in relation to various strains of Escherichia coli (Ec 41, Ec 42, Ec 44, Ec 45) isolated from meat products. Techniques such as Determination of Minimum Inhibitory Concentration were used (MIC) and Minimum Bactericidal Concentration (CBM). Furthermore, the method was used disk diffusion method to examine the interaction between O.
View Article and Find Full Text PDFEssential oil of Lippia origanoides as an anesthetic for Piaractus mesopotamicus: implications for induction and recovery times, ventilatory frequency and blood responses after biometric management.
Braz J Biol
January 2025
Universidade Federal de Mato Grosso do Sul - UFMS, Programa de Pós-graduação em Ciência Animal, Campo Grande, MS, Brasil.
This study evaluated the use of the essential oil of Lippia origanoides (EOLO) as an anesthetic for juvenile pacu, Piaractus mesopotamicus. Two experiments were performed. In Experiment I, anesthetic induction and recovery times and ventilatory frequency (VF) were determined for fish (n= 48; 29.
View Article and Find Full Text PDFEssential oil and phenolic compounds in different organs and developmental stages of Monarda didyma L., and their biological activity.
Planta
January 2025
Department of Vegetable and Medicinal Plants, Institute of Horticulture Sciences, Warsaw University of Life Sciences, 159 Nowoursynowska Street, 02-776, Warsaw, Poland.
Plant development has a greater impact on the chemical composition of inflorescences than of the leaves and stems of Monarda didyma plants. Monarda didyma L. is a well-known ornamental and aromatic plant.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!