In glioblastoma cells the receptor tyrosine kinase c-Met is upregulated in response to bevacizumab and plays an important role in promoting invasion and tumor recurrence. These data support novel links between VEGF-A and hepatocyte growth factor and suggest that c-Met and its signaling effectors may be effective targets for anti-invasive therapies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618531 | PMC |
| http://dx.doi.org/10.1158/1078-0432.CCR-13-0051 | DOI Listing |
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