Postural stabilization is required following perturbations or after transitioning to standing. The current research evaluated two available algorithms that utilize within-trial data to quantify standing following multi-planar transitions. Forty-five participants began each trial by assuming a static forward kneeling posture that ended with an auditory signal prompting transition to standing. Data from two force plates was collected at 100Hz for 20s starting with the transition. With one algorithm, using windows of various lengths, stabilization time was defined as when mean center of pressure (CoP) velocity of the current window was less than that for the mean of all subsequent windows. This algorithm produced significantly different stabilization times (1.3-6.9s) depending on the window length. In a second algorithm, a negative exponential mathematical model was fit to data within each trial (R(2)=0.93). This approach was easily implemented and produced results (mean=2.1s) with lower variability (SD=0.9s). Though approaches exist that adequately determine stabilization times in well-constrained uni-planar movements, there are limitations to generalizability. The negative exponential mathematical model evaluated in this study provides a promising method for systematically determining stabilization times for multi-planar movements.
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http://dx.doi.org/10.1016/j.gaitpost.2013.01.011 | DOI Listing |
JMIR Aging
January 2025
Institute of Mathematics and Computer Sciences, University of São Paulo, São Carlos SP, Brazil.
Background: The prevalence of stroke is high in both males and females, and it rises with age. Stroke often leads to sensor and motor issues, such as hemiparesis affecting one side of the body. Poststroke patients require torso stabilization exercises, but maintaining proper posture can be challenging due to their condition.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California 93106, United States.
Electrochemical aptamer-based (EAB) sensors are a molecular measurement platform that enables the continuous, real-time measurement of a wide range of drugs and biomarkers in situ in the living body. EAB sensors are fabricated by depositing a thiol-modified, target-binding aptamer on the surface of a gold electrode, followed by backfilling with an alkanethiol to form a self-assembled monolayer. And while the majority of previously described EAB sensors have employed hydroxyl-terminated monolayers, a handful of studies have shown that altering the monolayer headgroup can strongly affect sensor performance.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, P. R. China.
Flexible electronics have been rapidly advancing and have garnered significant interest in monitoring physiological activities and health conditions. However, flexible electronics are prone to detachment in humid environments, so developing human-friendly flexible electronic devices that can effectively monitor human movement under various aquatic conditions and function as flexible electrodes remains a significant challenge. Here, we report a strongly adherent, self-healing, and swelling-resistant conductive hydrogel formed by combining the dual synergistic effects of hydrogen bonding and dipole-dipole interactions.
View Article and Find Full Text PDFAnal Chem
January 2025
School of Basic Medical Sciences, Guangzhou Νational Laboratory, Guangzhou Medical University, Guangzhou 511436, China.
The farnesoid X receptor (FXR) regulates key physiological processes, such as bile acid homeostasis and lipid metabolism, making it an important target for drug discovery. However, the overactivation of FXR often leads to adverse effects. This study presents the development of a novel fluorescent probe utilizing the computer-aided drug design (CADD) approach to optimize linkers between more potent warhead and FITC fluorescent groups.
View Article and Find Full Text PDFMol Divers
January 2025
Department of Biosciences, Faculty of Science, Universiti Teknologi Malaysia, 81310, Johor Bahru, Johor, Malaysia.
Dengue is one of the most prevalent viruses transmitted by the Aedes aegypti mosquitoes. Currently, no specific medication is available to treat dengue diseases. The NS2B-NS3 protease is vital during post-translational processing, which is a key target in this study.
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