Cu-catalyzed A(3) coupling of ethoxyacetylene, pyrrolidine and salicylaldehydes led to a concomitant cycloisomerization followed by hydrolysis of the resultant vinyl ether to afford coumarins in a cascade process. The reaction proceeded through exclusive 6-endo-dig cyclization and is compatible with halo and keto groups giving coumarins in good to moderate yields.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566765 | PMC |
| http://dx.doi.org/10.3762/bjoc.9.21 | DOI Listing |
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