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Intrinsic feedbacks in MAPK signaling cascades lead to bistability and oscillations. | LitMetric

Intrinsic feedbacks in MAPK signaling cascades lead to bistability and oscillations.

Acta Biotheor

Institut Non Linéaire de Nice, UMR 7335 CNRS, University of Nice Sophia Antipolis, 1361 route des Lucioles, 06560 Valbonne, France.

Published: March 2013

AI Article Synopsis

Article Abstract

Previous studies have demonstrated that double phosphorylation of a protein can lead to bistability if some conditions are fulfilled. It was also shown that the signaling behavior of a covalent modification cycle can be quantitatively and, more importantly, qualitatively modified when this cycle is coupled to a signaling pathway as opposed to being isolated. This property was named retroactivity. These two results are studied together in this paper showing the existence of interesting phenomena--oscillations and bistability--in signaling cascades possessing at least one stage with a double-phosphorylation cycle as in MAPK cascades.

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Source
http://dx.doi.org/10.1007/s10441-013-9177-5DOI Listing

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