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Exploring the role of multimodal [F]F-PSMA-1007 PET/CT and multiparametric MRI data in predicting ISUP grading of primary prostate cancer.
Eur J Nucl Med Mol Imaging
January 2025
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Purpose: The study explores the role of multimodal imaging techniques, such as [F]F-PSMA-1007 PET/CT and multiparametric MRI (mpMRI), in predicting the ISUP (International Society of Urological Pathology) grading of prostate cancer. The goal is to enhance diagnostic accuracy and improve clinical decision-making by integrating these advanced imaging modalities with clinical variables. In particular, the study investigates the application of few-shot learning to address the challenge of limited data in prostate cancer imaging, which is often a common issue in medical research.
View Article and Find Full Text PDFLysophosphatidylcholine induces ceramide synthase-2 expression in primary culture model of astrocytopathy: potential therapeutic target in multiple sclerosis.
Mol Biol Rep
January 2025
Department of Pharmacology, School of Health Sciences, Central University of Punjab, Bathinda, 151401, India.
Background: Multiple sclerosis (MS) is a chronic autoimmune condition that damages the myelin sheath of neurons in the central nervous system, resulting in compromised nerve transmission and motor impairment. The astrocytopathy is considered one of the prominent etiological factor in the pathophysiology of demyelination in MS. The expression level of ceramide synthase-2 (CS-2) is yet to be established in the pathophysiology of astrocytopathy although the derailed ceramide biosynthetic pathways is well demonstrated in the pathophysiology of demyelination.
View Article and Find Full Text PDFPerspectives of healthcare workers on drone-enabled healthcare delivery in challenging terrains of Manipur and Nagaland, India: a qualitative research.
J Public Health Policy
January 2025
Indian Council of Medical Research, V. Ramalingaswami Bhawan, Ansari Nagar, New Delhi, 110029, India.
Collaborative initiatives of the drone industry and healthcare sector are becoming a pivotal step in restructuring healthcare service delivery in India. This paper documents knowledge and perceptions of healthcare workers from various districts of Manipur and Nagaland towards the use of drones for medical supply in the region. The study utilized 27 in-depth interviews with healthcare workers to collect qualitative data, which was then analyzed using NVivo 14 for thematic and content analysis.
View Article and Find Full Text PDFAn experimental comparison and user evaluation of three different dried plasma products.
Vox Sang
January 2025
Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden.
Background And Objectives: Access to blood components in pre-hospital bleeding resuscitation is challenging. Dried plasma is a logistically superior alternative, and new products are emerging. Therefore, we aimed to evaluate laboratory and practical differences in three differently produced dried plasma products.
View Article and Find Full Text PDFRecent progress in polysaccharide microsphere-based hemostatic material for intravascular and extravascular hemostasis: A review.
Int J Biol Macromol
January 2025
Shiyan Key Laboratory of Natural Medicine Nanoformulation Research, Hubei Key Laboratory of Embryonic Stem Cell Research, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China. Electronic address:
Hemorrhage, a common consequence of diseases, surgical procedures, and traffic accidents, poses a significant threat to public health. Effective hemostasis is crucial for patient survival and prognosis, particular in case of internal bleeding. While polysaccharide microsphere-based hemostatic materials have gained clinical acceptance due to their effectiveness, good biocompatibility, and versatility in both intravascular and extravascular hemostasis, they are limited by their single function and insufficient hemostatic properties.
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