AI Article Synopsis
- Light exposure influences the growth of living organisms, with excimer light (308 nm) showing better results than narrow-band ultraviolet B (NBUVB; 311 nm) in treating vitiligo by promoting melanoblast differentiation.
- Using mouse melanoblast cells, the study found that excimer light promotes differentiation through specific cellular pathways, while NBUVB does not trigger this response.
- The research highlights the importance of light intensity (irradiance) in future UVB therapies for pigmentation, suggesting it should be a key factor in treatment design.
Article Abstract
Light exposure modulates development of living organisms. In the field of medicine, light has frequently been used for regenerative purposes. Excimer light (308 nm) has demonstrated superior efficacy in treating vitiligo, a condition requiring development of melanoblasts and a model for studying nerve cell regeneration, as compared to narrow-band ultraviolet B (NBUVB; 311 nm). Using mouse-derived melanoblast cells to examine the pro-differentiation effects of these two light sources, we demonstrated that at equivalent fluence, excimer light induces melanoblast differentiation, while NBUVB failed to so. Mechanistically, activation of aryl hydrocarbon receptor pathway and nuclear translocation of epidermal growth factor receptor are involved in pro-differentiation effects of excimer light. Reduction in irradiance by filter abrogated the effects of excimer light in melanoblasts, even when equivalent fluence was delivered by the same light source. As ultraviolet B (UVB) irradiation is closely associated pigment cell development, future therapy employing UVB for pigmentation purposes should incorporate irradiance as a crucial specification.
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| http://dx.doi.org/10.1111/pcmr.12077 | DOI Listing |
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