AI Article Synopsis
- - Drug transport in the central nervous system is regulated by various transport proteins located at barriers like the blood-brain barrier, as well as within brain cells like astrocytes and neurons.
- - Key transporter families involved include the ATP-Binding Cassette and Solute Carrier families, which help manage the movement of both natural substances and drugs into and out of the brain.
- - These transport proteins are linked to several neurological conditions, such as HIV-encephalitis, Alzheimer's, and Parkinson's disease, highlighting their importance in understanding brain health.
Article Abstract
Drug transport in the central nervous system can be highly regulated by the expression of numerous influx and efflux transport proteins not only at the blood-brain barrier and blood-cerebrospinal fluid barrier but also in brain parenchymal cellular compartments (i.e., astrocytes, microglia, neurons). In particular, members of the ATP-Binding Cassette membrane-associated transporter superfamily and Solute Carrier family are known to be involved in the traffic of several endobiotics and xenobiotics (including drugs) into and out ofthe brain. These transport proteins have also been implicated in a number of neurological disorders including HIV-encephalitis, Alzheimer's disease, Parkinson's disease and neoplasia. This chapter summarizes recent knowledge on the role of drug transporters in the brain.
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