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The Rise of Type 2 Diabetes in Children and Adolescents: An Emerging Pandemic.
Diabetes Metab Res Rev
January 2025
Department of Human Genetics, Guru Nanak Dev University, Amritsar, India.
Aim: This review explores the increasing prevalence of Type 2 Diabetes Mellitus (T2DM) in children and adolescents, focusing on its etiology, risk factors, complications, and the importance of early detection and management. It also highlights the need for a multidisciplinary, family-centered approach in managing T2DM in pediatric populations, with an emphasis on nutrition, exercise, and lifestyle interventions.
Materials And Methods: A literature review was conducted using PubMed, Google Scholar, and Scopus to incorporate studies from 2015 to 2024 on T2DM in youths/adolescents/children, focusing on epidemiology, risk factors, and prevention strategies.
Delayed Postoperative Radiotherapy in Head & Neck Cancers-A Systematic Review and Meta-Analysis.
Laryngoscope
January 2025
Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada.
Objectives: To evaluate the impact of delayed postoperative radiotherapy (PORT) on overall survival (OS) in patients with head and neck cancers (HNC).
Data Sources: A systematic review and meta-analysis were conducted by searching MEDLINE, Embase, CENTRAL, Web of Science, and CINAHL databases.
Review Methods: Studies assessing the impact of delayed PORT in adult HNC patients were included.
Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction with significant thromboembolic risk. Though there are models for use of non-heparin anticoagulants, heparin remains the preferred anticoagulant in many operative settings, especially cardiovascular surgery and percutaneous cardiac intervention. The natural history of HIT can be stereotyped into phases using HIT laboratory testing to guide clinical management and determine whether heparin re-exposure can be considered.
View Article and Find Full Text PDFMetastasis-directed therapy in oligometastatic and oligoprogressive renal cell carcinoma.
Curr Opin Urol
December 2024
Division of Urologic Oncology.
Purpose Of Review: This review addresses the evolving role of metastasis-directed therapy (MDT) in the management of oligometastatic and oligoprogressive renal cell carcinoma (RCC). With advances in both surgical techniques and stereotactic ablative radiotherapy (SABR), it is timely to explore how MDT can improve patient outcomes in these distinct disease states. The review highlights the potential of MDT to delay systemic therapy and improve quality of life while noting the lack of randomized clinical trial data guiding its use.
View Article and Find Full Text PDFAssessing the impact of the COVID-19 pandemic on neglected tropical diseases in India: a perspective.
Front Public Health
January 2025
Indian Institute of Public Health Delhi, New Delhi, India.
The COVID-19 pandemic has significantly challenged healthcare systems worldwide, particularly in India, a country already burdened with a high prevalence of Neglected Tropical Diseases (NTDs). This perspective examines the pandemic's direct and indirect impacts on the prevalence, diagnosis, and management of NTDs in India. Using a narrative review approach, we analyzed literature published between January 2020 and September 2023 from databases such as PubMed, Scopus, and Google Scholar, along with grey literature.
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