Threat of the use of biological pathogens is still real. The degree of preparation assistance at various stages directly affects the efficiency of operations in the event of mass cases. The need for and scope of assistance given in relation to current recommendations, and our own experience with patients with severe infections. Principle of segregation and evacuation steps included in the basic hospital procedures.
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Neurosurg Focus
October 2023
1Department of Neurosurgery, Inova Fairfax Medical Campus, Falls Church, Virginia.
Objective: The optimal perioperative management of antithrombotic therapy (ATT) in patients requiring urgent neurosurgical intervention for subdural hematoma (SDH) is poorly understood. The delicate equilibrium of effective hemostasis while preventing thrombosis is complex and relies on numerous factors such as indication for and type of ATT, medical comorbidities, and extent of neurological injury. This study aimed to analyze the impact of ATT and reversal strategies on surgical outcomes to highlight current challenges in the management of these high-risk patients.
View Article and Find Full Text PDFSensors (Basel)
May 2023
Military Institute of Medicine-National Research Institute, Szaserów 128, 04-141 Warsaw, Poland.
The area of military operations is a big challenge for medical support. A particularly important factor that allows medical services to react quickly in the case of mass casualties is the ability to rapidly evacuation of wounded soldiers from a battlefield. To meet this requirement, an effective medical evacuation system is essential.
View Article and Find Full Text PDFBiophys J
May 2022
Center for Complex Biological Systems, University of California, Irvine; Department of Chemical & Biomolecular Engineering, University of California, Irvine. Electronic address:
The activation of T cells, key players of the immune system, involves local evacuation of phosphatase CD45 from a region of the T cell's surface, segregating it from the T cell receptor. What drives this evacuation? In the presence of antigen, what ensures evacuation happens in the subsecond timescales necessary to initiate signaling? In the absence of antigen, what mechanisms ensure that evacuation does not happen spontaneously, which could cause signaling errors? Phenomena known to influence spatial organization of CD45 or similar surface molecules include diffusive motion in the lipid bilayer, oligomerization reactions, and mechanical compression against a nearby surface, such as that of the cell presenting the antigen. Computer simulations can investigate hypothesized spatiotemporal mechanisms of T cell signaling.
View Article and Find Full Text PDFPLoS One
November 2021
Department of Urology, Foundation IRCCS Ca' Granda-Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
Background: Bipolar Transurethral Enucleation of the Prostate (B-TUEP) is recommended as a first-choice treatment for benign prostatic obstruction in prostates >80 ml. Differently, B-TUEP is only considered as an alternative option after TURP for smaller prostates (30-80 ml). The aim of our study is to assess the relation between prostate size and surgical outcomes after B-TUEP.
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