[Unusual work schedule: mathematical and pharmacokinetic models to adjust the occupational exposure limit of the chemical agents].

Exposure to chemicals in unusual work shifts can require adjustment of the occupational limit values to assure adequate protection of the exposed workers. The study introduces a comparative analysis of the mathematical and pharmacokinetic models to calculate the adjustment factors and provides a computer-assisted toolkit to obtain the reduction factors for exposures to single chemical agent and mixtures in unusual work schedule.