AI Article Synopsis
- Hyperthyroidism can decrease sperm motility and increase oxidative stress in testes, leading to male reproductive issues.
- Resveratrol (RSV), an antioxidant, was tested on hyperthyroid rats and successfully improved sperm motility and antioxidant status in their testes without causing effects in normal rats.
- The findings suggest that RSV could be a potential treatment to safeguard sperm motility and testicular health in individuals with hyperthyroidism.
Article Abstract
Hyperthyroidism may lead to a loss of sperm motility and an increase in oxidative stress (OS) in testes and may cause male reproductive disorders. Thus, the use of compounds with antioxidant properties may be a strategy for preventing these disorders. The effect of resveratrol (RSV) on sperm motility and on variables of the antioxidant status in the testes of rats with triiodothyronine-induced hyperthyroidism (100μg/kg) was investigated. Hyperthyroid rats presented lower sperm motility, higher levels of lipid hydroperoxides and thiobarbituric reactive substances, lower catalase and glutathione peroxidase activities and higher glutathione-S-transferase activity in their testes than control animals. RSV treatment (1mg/kg and 10mg/kg) was able to prevent these effects in the hyperthyroid rats and had no effect in the control animals. In conclusion, RSV might be a strategy for therapeutic intervention to preserve sperm motility and to prevent OS in testes, preserving testicular function in those with hyperthyroidism.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.reprotox.2013.01.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Glucose-6-Phosphatase (G6Pase), a key enzyme in gluconeogenesis and glycogenolysis in the mammalian liver and kidney, converts glucose-6-phosphate to glucose for maintaining systemic blood glucose homeostasis during nutrient deprivation. However, its function has remained elusive in insects, which have no need for G6Pase in sugar homeostasis since they convert glucose-6-phosphate to trehalose, their main circulating sugar, via trehalose phosphate synthase (TPS1). In this study we identify an unexpected and essential requirement for G6Pase in male fertility, specifically to produce motile sperm.
View Article and Find Full Text PDFPurpose Subfertility is a well-known aftermath of treatment of testicular germ cell tumours (GCTs). Growing evidence suggests reduced semen quality also before therapy. The present study aimed to evaluate pre-orchiectomy semen parameters in GCT patients and to compare the results with controls.
View Article and Find Full Text PDFThe effect of consecutive ejaculation on the sperm parameters in the oligo-astheno-teratozoospermia (OAT) men.
Zygote
January 2025
Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Recently, the World Health Organization recommendation for abstinence time for semen analysis has been challenged in some studies and many of them have supported the advantages of a second short abstinence ejaculation. More evidence is needed to approve this for clinical use. This study aimed to compare the average routine abstinence time (2-7 days) with the short time (1-2 h) on sperm quality based on functional parameters in a population of oligo-astheno-teratozoospermia (OAT) men.
View Article and Find Full Text PDFProbing the impact of commercial cryoprotectants and freezing technique on the motility of human spermatozoa cryopreserved onto extremely water-repellent soot-coated surfaces.
Cryobiology
January 2025
Specialized Surgical Hospital "Doctor Malinov", 46, Gotse Delchev blvd., 1860 Sofia, Bulgaria.
The cryopreservation of human spermatozoa is an integral part of cryobiology, aiming to support the in-vitro fertilization. The latter relies on the availability of as much as possible reproductively active spermatozoa, whose number after thawing decreases due to the accompanied freezing injury and the cytotoxicity of cryoprotectants. An innovative option to circumvent these obstacles is to make the freezing interface non-wettable, by coating it with rapeseed oil soot possessing intrinsic cryoprotective properties, delaying the ice formation and possibly providing identical rates of intracellular dehydration and extracellular crystallization.
View Article and Find Full Text PDFSeroprevalence of HSV-2 in multiple subgroups of infertile men with abnormal sperm parameters and those seeking sex selection: a case-control study.
BMC Infect Dis
January 2025
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Background: Herpes simplex virus type 2 (HSV-2) is a common sexually transmitted infection (STI) primarily acquired through sexual contact. In 2000, the World Health Organization (WHO) for the first time reported the association of STIs with male infertility. Infertility is described as the inability to achieve a clinical pregnancy after engaging in regular, unprotected sexual intercourse for a year or more.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!