When a pinhole collimator is to be used for tomographic studies the standard SPECT software has to be modified so as to avoid serious image distortion outside the axis of rotation. The MTF measured at the axis of rotation shows that the better resolution of the pinhole collimator as compared with that of a parallel-hole collimator improves the tomographic image. The low sensitivity of the pinhole collimator excludes the use of an aperture smaller than 6 mm for patient tomographic studies where the activity which may be administered is restricted.
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Int J Comput Assist Radiol Surg
December 2024
Graduate School of Science and Technology, Hirosaki University, Hirosaki, Japan.
Purpose: We are developing a three-dimensional X-ray fluorescence computed tomography (3D XFCT) system using non-radioactive-labeled compounds for preclinical studies as a new modality that provides images of biological functions. Improvements in image quality and detection limits are required for the in vivo imaging. The aim of this study was to improve the quality of XFCT images by applying a deep image prior (DIP), which is a type of convolutional neural network, to projection images as a pre-denoising method, and then compare with DIP post-denoising.
View Article and Find Full Text PDFPhys Med
December 2024
Department of Radiation Oncology, TUM School of Medicine and Health and Klinikum rechts der Isar, TUM University Hospital, Technical University of Munich (TUM), Munich, Germany; Institute of Radiation Medicine, Helmholtz Zentrum München GmbH, German Research Center for Environmental Health, Neuherberg, Germany; Forschungs-Neutronenquelle Heinz Maier-Leibnitz Zentrum (FRM II), Technical University of Munich (TUM), Garching, Germany.
Purpose: Microbeam radiation therapy (MRT) has shown superior healthy tissue sparing at equal tumour control probabilities compared to conventional radiation therapy in many preclinical studies. The limitation to preclinical research arises from a lack of suitable radiation sources for clinical application of MRT due to high demands on beam quality. To overcome these limitations, we developed and built the first prototype of a line-focus X-ray tube (LFXT).
View Article and Find Full Text PDFRadiol Phys Technol
December 2024
Division of Medical Quantum Science, Department of Health Sciences, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.
Phys Med Biol
November 2024
Department of Radiation Science and Technology, Delft University of Technology, Delft, The Netherlands.
Advanced pinhole collimation geometries optimized for preclinical high-energyimaging facilitate applications such asandemitter imaging, simultaneous multi-isotope PET and PET/SPECT, and positron range-free PET. These geometries replace each pinhole with a group of clustered pinholes (CPs) featuring smaller individual pinhole opening angles (POAs), enabling sub-mm resolution imaging up to ∼1 MeV. Further narrowing POAs while retaining field-of-view (FOV) may enhance high-energy imaging but faces geometrical constraints.
View Article and Find Full Text PDFPhys Med
November 2024
Faculty of Science and Engineering, Waseda University, Japan.
Prompt gammas imaging (PGI) is a promising method for observing a beam's shape and estimating the range of the beam from outside a subject. However 2-dimensional images of prompt gammas (PGs) during irradiation of protons were still difficult to measure. To achieve PGI, we developed a new gamma camera and imaged PGs while irradiating a phantom by proton beams.
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