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The World's Oldest Description of Oromandibular Dystonia.
Mov Disord Clin Pract
January 2025
Department of Oral and Maxillofacial Surgery, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan.
Treatment with OnabotulinumtoxinA for Oromandibular Dystonia: A Systematic Review and Meta-Analysis.
Toxins (Basel)
December 2024
Department of Neurology, Tokushima University, Tokushima 770-8503, Japan.
Article Synopsis
- Oromandibular dystonia (OMD) is a condition causing muscle contractions in the jaw and related areas, and this study analyzed the effects of botulinum toxin (onabotulinumtoxinA) as a treatment.
- A meta-analysis of 26 studies with 1103 patients showed that 96.2% experienced a positive response to the injections, with 88.9% achieving significant improvement of over 50%.
- Although 17.8% of patients had adverse effects, mainly dysphagia (10.1%), the overall findings suggest that botulinum toxin is an effective treatment for OMD but further studies are needed for more conclusive results.
Optimal botulinum toxin therapy of dystonia in Germany: what would it cost?
J Neural Transm (Vienna)
December 2024
IAB - Interdiciplinary Working Group for Movement Disorders, Hamburg, Germany.
Botulinum toxin (BT) therapy is the therapy of choice for most forms of dystonia. We want to describe its costs, if all dystonia patients in Germany would have access to optimal BT therapy. For this, we combined the latest data on epidemiology of dystonia and dosing of BT therapy for dystonia.
View Article and Find Full Text PDFSpasmodic dysphonia: the need for a combined neurological and phoniatric approach.
J Neural Transm (Vienna)
December 2024
IAB - Interdisciplinary Working Group for Movement Disorders, Hamburg, Germany.
Spasmodic dysphonia (SD) is now generally considered to be a task-specific focal dystonia. For the first time, we wanted to explore the relationship between SD and dystonia from a combined neurological and phoniatric perspective. For this, we studied 115 patients with non-psychogenic SD by a combined neurological and phoniatric evaluation.
View Article and Find Full Text PDFRisk of Spreading in Adult-onset Dystonia.
Tremor Other Hyperkinet Mov (N Y)
December 2024
Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Neurology, Istanbul, Turkey.
Article Synopsis
- Adult-onset dystonia can spread to other body parts, but it's less common than in childhood-onset cases.
- The study analyzed medical records of 434 adult patients to identify clinical factors linked to whether their dystonia symptoms spread.
- Out of the patients, 11.1% experienced spreading, with older age at onset being a significant risk factor; however, the exact mechanisms and genetic influences behind this spreading are still not fully understood.
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