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Development of a novel multi-epitope subunit mRNA vaccine candidate to combat Acinetobacter baumannii.
Sci Rep
January 2025
Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Acinetobacter baumannii, an opportunistic bacterium prevalent in various environment, is a significant cause of nosocomial infections in ICUs. As the causative agent of pneumonia, septicemia, and meningitis, A. baumannii typically exhibits multidrug resistance and is associated with poor prognosis, thus led to a challenge for researchers in developing new treatment and prevention methods.
View Article and Find Full Text PDFIn endemic areas with a compatible epidemiological context, clinicians should consider anthrax as a potential diagnosis. The disease can present with diverse clinical manifestations, including cutaneous, gastrointestinal, respiratory, or central nervous system infections.
View Article and Find Full Text PDFCerebrospinal fluid proteomics reveals the innate immunity and blood-brain barrier dysregulation in a patient with multidrug-resistant ventriculitis treated with intrathecal and intravenous polymyxin B.
Heliyon
December 2024
Department of Critical Care Medicine, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), Shenzhen, 518020, China.
is a major pathogen of nosocomial meningitis and ventriculitis. Due to very limited antibiotic treatment options, polymyxins are often used as a last-line therapy. To optimise polymyxin use in the intraventricular environment, cerebrospinal fluid (CSF) proteomics was employed to investigate host-pathogen-polymyxin interactions in a 69-year-old patient with multidrug-resistant ventriculitis treated with a combination of intrathecal (ITH; 50,000 IU q24h/q48h), intraventricular (IVT; 50,000 IU q48h), and intravenous (500,000 IU, q12h) polymyxin B.
View Article and Find Full Text PDFIntraventricular Tigecycline Therapy for Ventriculoperitoneal Shunt-Related Septic Shock Caused by Colistin-Resistant : A Case Report.
Infect Dis Clin Microbiol
December 2024
Department of Anesthesiology and Critical Care Unit, Başkent University School of Medicine, Ankara, Türkiye.
Article Synopsis
- Ventriculoperitoneal shunts (VPSs) are essential for treating certain medical conditions, but they come with complications, particularly in light of increasing antibiotic resistance.
- A case was presented involving a serious VPS infection caused by bacteria resistant to colistin, which was successfully treated with intraventricular tigecycline, showing no negative side effects.
- The effectiveness of intraventricular tigecycline against colistin-resistant infections is encouraging, but more research is needed to determine proper dosages and establish guidelines for its use.
Rare case of resistant associated meningitis due to intrathecal catheter.
Surg Neurol Int
November 2024
Department of Neurosurgery, College of Medicine and Life Sciences, University of Toledo, Toledo, United States.
Background: (AX) is an aerobic Gram-negative opportunistic bacteria known to inhabit various environments and is most commonly associated with nosocomial infections in immune-compromised patients. Although rare, AX can cause a variety of neurological infections, such as meningitis, ventriculitis, and osteomyelitis. Intravascular catheters, intrathecal pumps, and contaminated surgical instruments are potential vectors for such patients.
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