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Short-term exposure to ozone and levels of exhaled nitric oxide.
Epidemiology
January 2014
From the aOccupational and Environmental Medicine, Department of Public Health and Clinical Medicine, University of Umeå, Umeå, Sweden; bOccupational and Environmental Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; and cAstraZeneca R&D, Mölndal, Sweden.
Background: Adverse effects of air pollution include respiratory inflammation. A few epidemiologic studies have shown elevations in the fraction of exhaled nitric oxide, a marker of airway inflammation, after exposure to traffic-related pollutants.
Methods: We examined whether short-term exposures to ozone (O3), oxides of nitrogen (NOx), or particulate matter <10 μm (PM10) were associated with proximal and distal airway inflammation.
Procainamide and its major metabolite, N-acetyl procainamide (NAPA), prolong the QTc interval and can promote potentially fatal ventricular arrhythmias. Excretion of procainamide and NAPA is reduced in patients with chronic kidney disease (CKD) resulting in drug accumulation and toxicity. The elimination of procainamide or NAPA in patients undergoing continuous renal replacement therapy (CRRT) has not been evaluated increasing the risk for subtherapeutic or toxic dosing regimens.
View Article and Find Full Text PDFOrgan preservation in patients with invasive bladder cancer: initial results of an intensified protocol of transurethral surgery and radiation therapy plus concurrent cisplatin and 5-fluorouracil.
Int J Radiat Oncol Biol Phys
April 2002
Department of Radiation Therapy, University of Erlangen, Erlangen, Germany.
Purpose: To assess safety, tolerance, and disease control of transurethral resection of the bladder tumor (TURB) plus concurrent cisplatin, 5-fluorouracil (5-FU), and radiation therapy (RT) with selective organ preservation in patients with bladder cancer.
Patients And Methods: Forty-five patients with muscle-invading or high-risk T1 (G3, associated carcinoma in situ, multifocality, >5 cm) bladder cancer were entered into a protocol of TURB followed by concurrent cisplatin (20 mg/m(2)/day, 20-min infusion) and 5-FU (600 mg/m(2)/day, 120-hour continuous infusion), administered on Day 1-5 and 29-33 of RT (single dose 1.8 Gy, total dose to the bladder 54-59.
Body temperature and mood variations during forced desynchronization in winter depression: a preliminary report.
Biol Psychiatry
February 2000
Department of Biological Psychiatry, Psychiatric University Clinic, Groningen, The Netherlands.
Background: It has been suggested that certain abnormalities (e.g., in phase or amplitude) of the circadian pacemaker underlie seasonal affective disorder.
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