A highly stable tunable dual-wavelength fiber laser (TDWFL) using graphene as a means to generate a highly stable output is proposed and generated. The TDWFL comprises a 1 m long, highly doped erbium-doped fiber (EDF) acting as the linear gain medium, with a 24-channel arrayed waveguide grating acting as a wavelength slicer as well as a tuning mechanism to generate different wavelength pairs. The tuned wavelength pairs can range from 0.8 to 18.2 nm. A few layers of graphene are incorporated into the laser cavity to induce the four-wave-mixing effect, which stabilizes the dual-wavelength output by suppressing the mode competition that arises as a result of homogenous broadening in the EDF.
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http://dx.doi.org/10.1364/AO.52.000818 | DOI Listing |
World J Gastrointest Oncol
January 2025
Department of Radiology, The Third Affiliated Hospital of Guangxi Medical University, Nanning 530031, Guangxi Zhuang Autonomous Region, China.
Background: Microvascular invasion (MVI) is a significant risk factor for recurrence and metastasis following hepatocellular carcinoma (HCC) surgery. Currently, there is a paucity of preoperative evaluation approaches for MVI.
Aim: To investigate the predictive value of texture features and radiological signs based on multiparametric magnetic resonance imaging in the non-invasive preoperative prediction of MVI in HCC.
ACS Pharmacol Transl Sci
January 2025
Department of Cell and Molecular Biology, University of Rhode Island, 120 Flagg Rd, Kingston, Rhode Island 02881, United States.
Despite the enthusiasm for targeted cancer therapies in preclinical studies and the success of a select few drugs, many promising drug candidates fail in clinical trials. The gap between preclinical promise and clinical outcomes underscores the need to investigate factors influencing the success or failure of targeted therapies. Dasatinib, an inhibitor of Abl and Src protein tyrosine kinases, is highly effective toward chronic myeloid leukemia (CML) by targeting BCR-Abl, but it is ineffective against solid tumors when targeting Src kinases.
View Article and Find Full Text PDFMetasurfaces offer a powerful tool to realize label-free and highly sensitive Raman spectroscopy. Embedding metasurfaces into microfluidic channels is promising to establish a new characterizing platform for microfluids. In this Letter, we present a highly stable method for improving the Raman scattering intensity of biological microfluids by using a microfluidic chip embedded with a plasmonic metasurface.
View Article and Find Full Text PDFNat Nanotechnol
January 2025
Key Laboratory of Bio-inspired Materials and Interfacial Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China.
The miniaturization of light-emitting diodes (LEDs) is pivotal in ultrahigh-resolution displays. Metal-halide perovskites promise efficient light emission, long-range carrier transport and scalable manufacturing for bright microscale LED (micro-LED) displays. However, thin-film perovskites with inhomogeneous spatial distribution of light emission and unstable surface under lithography are incompatible with the micro-LED devices.
View Article and Find Full Text PDFNature
January 2025
Department of Biochemistry, University of Washington, Seattle, WA, USA.
Snakebite envenoming remains a devastating and neglected tropical disease, claiming over 100,000 lives annually and causing severe complications and long-lasting disabilities for many more. Three-finger toxins (3FTx) are highly toxic components of elapid snake venoms that can cause diverse pathologies, including severe tissue damage and inhibition of nicotinic acetylcholine receptors, resulting in life-threatening neurotoxicity. At present, the only available treatments for snakebites consist of polyclonal antibodies derived from the plasma of immunized animals, which have high cost and limited efficacy against 3FTxs.
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