Improved total synthesis of incednam.

J Antibiot (Tokyo)

Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.

Published: March 2013

An alternative and improved total synthesis of incednam, the aglycon of the 24-membered macrolactam glycoside antibiotic incednine, was accomplished. The synthesis was realized via construction of the 24-membered macrocycle using intramolecular ring-closing olefin metathesis reaction as a key step.

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Source
http://dx.doi.org/10.1038/ja.2013.4DOI Listing

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