Inhalation exposure to ambient ultrafine particles (UFP) has been shown to induce adverse health effects such as respiratory and cardiovascular mortality. Human exposure to particles of outdoor origin often occurs indoors due to entry of UFP into buildings. The objective of the present study is to investigate entry of UFP into a building considering building operational characteristics and their size-dependent effects on UFP concentrations. Indoor and outdoor UFP concentrations along with air change rates were continuously measured in a full-scale test building. Estimates of infiltration factor, penetration coefficient, and deposition rate have been made for a range of particle sizes from 4 to 100 nm. The results show that UFP infiltration factor varies with particle diameter, window position, air change rate, and central fan operation. When the central fan was on continuously, the average infiltration factor ranged from 0.26 (particles <10 nm) to 0.82 (particles >90 nm) for two large window openings, and from 0.07 to 0.60 for two small window openings. Under the central fan-off condition, the average infiltration factor ranged from 0.25 (particles <10 nm) to 0.72 (particles >90 nm) for two small window openings, while it ranged from 0.01 to 0.48 with all windows closed. Larger window openings led to higher infiltration factors due to the larger extent of particle penetration into the building. The fan operation mode (on vs off) also has a strong impact, as the infiltration factor was consistently lower (up to 40%) when the fan was on due to additional particle deposition loss to the furnace filter and duct surfaces.
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Viruses
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Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
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State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
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Centre of Materials and Civil Engineering for Sustainability (C-MADE), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal.
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View Article and Find Full Text PDFInt J Mol Sci
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Health Sciences Postgraduate Program, São Francisco University, Av. São Francisco de Assis, 218, Bragança Paulista, Sao Paulo 12916-900, Brazil.
The global increase in cancer cases and mortality has been associated with inflammatory processes, in which chemokines play crucial roles. These molecules, a subfamily of cytokines, are essential for the migration, adhesion, interaction, and positioning of immune cells throughout the body. Chemokines primarily originate in response to pathogenic stimuli and inflammatory cytokines.
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