In Chiapas, a total of 209 new cases of childhood cancers were registered between 1996 and 2007. Of these cases, 60.3% were composed of leukemias (32.1%), central nervous system tumors (CNST, 18.2%), and lymphomas (10.0%). Chiapas had the highest frequency of retinoblastoma (Rb, 9.6%). Not only did Chiapas have the highest incidence of childhood cancers overall (174.2) (all rates per 1000 000 children/year), but also the highest incidences of CNST, Rb, germ cell tumors, and carcinomas (32.5, 21.4, 10.9, and 4.2, respectively). By age, the highest incidence was found for those less than five years of age. The male/female ratio was 1.1. The incidence showed a trends to decrease (average annual percent change -9.8; CI 95% -13.6, -5.8). Of children with solid tumors, 58.7 % had been diagnosed with either stage III or IV.
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