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Selective activation of mesoscale functional circuits via multichannel infrared stimulation of cortical columns in ultra-high-field 7T MRI.
Cell Rep Methods
January 2025
Department of Neurosurgery of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310029, China; Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou 310029, China; National Key Laboratory of Brain and Computer Intelligence, Zhejiang University, Hangzhou 310058, China; Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China; MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310012, China. Electronic address:
To restore vision in the blind, advances in visual cortical prosthetics (VCPs) have offered high-channel-count electrical interfaces. Here, we design a 100-fiber optical bundle interface apposed to known feature-specific (color, shape, motion, and depth) functional columns that populate the visual cortex in humans, primates, and cats. Based on a non-viral optical stimulation method (INS, infrared neural stimulation; 1,875 nm), it can deliver dynamic patterns of stimulation, is non-penetrating and non-damaging to tissue, and is movable and removable.
View Article and Find Full Text PDFFunctional MRI for stereoscopic vision analysis: an experimental design.
Surg Radiol Anat
January 2025
Anatomy Department, University of Western Brittany (UBO), Brest, France.
Purpose: The aim was to establish a functional MRI protocol for analyzing human stereoscopic vision in clinical practice. The feasibility was established in a cohort of 9 healthy subjects to determine the functional cortical areas responsible for virtually relief vision.
Methods: Nine healthy right-handed subjects underwent orthoptic examination and functional MRI.
Relationship between functional structures and horizontal connections in macaque inferior temporal cortex.
Sci Rep
January 2025
Department of Neurosurgery of the Second Affiliated Hospital, Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou, China.
Horizontal connections in anterior inferior temporal cortex (ITC) are thought to play an important role in object recognition by integrating information across spatially separated functional columns, but their functional organization remains unclear. Using a combination of optical imaging, electrophysiological recording, and anatomical tracing, we investigated the relationship between stimulus-response maps and patterns of horizontal axon terminals in the macaque ITC. In contrast to the "like-to-like" connectivity observed in the early visual cortex, we found that horizontal axons in ITC do not preferentially connect sites with similar object selectivity.
View Article and Find Full Text PDFAnisotropy of the Orientation Selectivity in the Visual Cortex Area 18 of Cats Reared Under Normal and Altered Visual Experience.
Eur J Neurosci
January 2025
Pavlov Institute of Physiology RAS, Saint-Petersburg, Russia.
The "oblique effect" refers to the reduced visual performance for stimuli presented at oblique orientations compared to those at cardinal orientations. In the cortex, neurons that respond to specific orientations are organized into orientation columns. This raises the question: Are the orientation signals in the iso-orientation columns associated with cardinal orientations the same as those in the iso-orientation columns associated with oblique orientations, and is this signal influenced by experience? To explore this, iso-orientation columns in visual area 18 were examined using optical imaging techniques.
View Article and Find Full Text PDFObstructive sleep apnea and structural and functional brain alterations: a brain-wide investigation from clinical association to genetic causality.
BMC Med
January 2025
Sleep Medicine Center, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, NO.28 Qiaozhong Mid Road, Guangzhou, Guangdong, 510160, China.
Background: Obstructive sleep apnea (OSA) is linked to brain alterations, but the specific regions affected and the causal associations between these changes remain unclear.
Methods: We studied 20 pairs of age-, sex-, BMI-, and education- matched OSA patients and healthy controls using multimodal magnetic resonance imaging (MRI) from August 2019 to February 2020. Additionally, large-scale Mendelian randomization analyses were performed using genome-wide association study (GWAS) data on OSA and 3935 brain imaging-derived phenotypes (IDPs), assessed in up to 33,224 individuals between December 2023 and March 2024, to explore potential genetic causality between OSA and alterations in whole brain structure and function.
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