AI Article Synopsis
- Human cytomegalovirus infections significantly worsen health outcomes for immunosuppressed organ transplant recipients, impacting both morbidity and graft survival.
- Recent research highlights the critical role of CD4(+) T cells in antiviral T-cell therapy, traditionally overshadowed by the focus on CD8(+) T cells.
- CD4(+) T cells display strong functionality during viral challenges and contribute to the effectiveness of CD8(+) T-cell responses, indicating their importance for improving therapeutic outcomes in organ transplant patients.
Article Abstract
Human cytomegalovirus infections have a major negative effect on morbidity and mortality of immunosuppressed allograft recipients and indirectly on graft function and survival. The adoptive antiviral T-cell therapy is a novel therapeutic tool to restore immune competence after solid organ transplantation. Till now, the antiviral T-cell products mainly focused on cytotoxic CD8(+) T cells, whereas CD4(+) T cells played a minor role. Here, we demonstrate the importance of CD4(+) T cells within T-cell lines specific for human cytomegalovirus besides its essential support for the quality of CD8(+) T-cell memory. Virus-specific CD4(+) T cells elicit profound functionality after rechallenge (multicytokine secretors, CD137, CD154, and CD107a expression and killing of infected target cells). The CD4(+) T cells show predominantly a Th1 phenotype with cytolytic properties that is mainly perforin-dependent. The data demonstrate the significance of CD4(+) T cells within T-cell products to achieve a successful adoption with enhanced efficacy.
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| http://dx.doi.org/10.1097/CJI.0b013e31827b87cc | DOI Listing |
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