There is accumulating evidence that aggregating, misfolded proteins may have an impact on autophagic function, suggesting that this could be a secondary pathological mechanism in many diseases. In this review, we focus on the role of autophagy in four major neurodegenerative diseases: Alzheimer disease (AD), Huntington's disease (HD), Parkinson's disease (PD) and amyotropic lateral sclerosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647215 | PMC |
| http://dx.doi.org/10.1038/aps.2012.189 | DOI Listing |
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