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Aim: To study the role of iodine, selenium and zinc in the pathogenesis of iodine deficiency and autoimmune thyroid diseases and scientifically substantiate the choice of security biomarkers and analytical methods for determination.
Materials And Methods: Serum iodine (I), selenium (Se), and zinc (Zn) concentrations were measured using inductively coupled plasma ionization tandem mass spectrometry (Agilent 8900 ICP-MS Triple Quad); by chemiluminescent immunoassay on an automatic analyzer Architect i2000 - TSH and AT-TPO in blood serum; by enzyme immunoassay - ZnT8A; biochemical method - ALP, SOD1 in 1150 people aged from 18 to 65 years (the average age of the subjects was 40±5 years). Ultrasound of the thyroid gland was performed in the supine position using a portable ultrasound machine LOGIQe with a multifrequency linear sensor 10-15 MHz; during the study, the volume of the thyroid gland, the presence of nodules and their characteristics according to the TIRADS classification, the structure of the thyroid gland and its echogenicity were assessed.
Association between volume of processed plasma and total bilirubin reduction during plasma adsorption for severe liver disease.
Eur J Med Res
March 2025
Center of Infectious Diseases, West China Hospital of Sichuan University, No.37 GuoXue Xiang, Wuhou District, Chengdu, 610041, China.
Background: The double plasma molecular adsorption system (DPMAS) is a crucial therapeutic modality for the management of severe liver disease. Current literature reports considerable variability in the volume of processed plasma (VPP) utilized during DPMAS treatment, and there is currently no consensus on the appropriate VPP. We aimed to investigate the relationship between VPP and changes in total bilirubin levels during DPMAS treatment.
View Article and Find Full Text PDFThyroid function and multiple sclerosis: a two-sample mendelian randomization study and mediation analysis.
Sci Rep
March 2025
State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.
Multiple sclerosis (MS) is a prevalent neurological disorder with a complex etiology, often associated with thyroid function. However, the causal relationship between these two conditions remains poorly understood. This study aimed to elucidate the causal relationship between thyroid function and MS using a bidirectional Mendelian randomization (MR) approach and to investigate the potential mediating role of immune cells.
View Article and Find Full Text PDFCafestol and kahweol concentrations in workplace machine coffee compared with conventional brewing methods.
Nutr Metab Cardiovasc Dis
February 2025
Uppsala University, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism Unit, Sweden; Center for Clinical Research Dalarna, Falun, Sweden. Electronic address:
Background And Aims: Unfiltered coffee contains high concentrations of cholesterol-raising diterpenes. We aimed to measure the levels of diterpenes in machine coffee.
Methods And Results: Coffee samples were collected from Swedish workplaces and compared with home-made coffee brews.
Causal Relationships Between Inflammatory Cytokines and Sepsis: A Mendelian Randomization Study.
Ann Clin Lab Sci
January 2025
Department of Intensive Care Unit (ICU), Liuzhou Hospital of Traditional Chinese Medicine, Liuzhou, China
Objective: The complex interplay between inflammatory cytokines and sepsis is not well understood. This study employs Mendelian Randomization (MR) to investigate the causal relationships between various inflammatory cytokines and sepsis, aiming to elucidate the underlying mechanisms and potential therapeutic targets.
Methods: This study employed a bidirectional MR approach to investigate the causal effects of inflammatory cytokines on sepsis and vice versa.
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