Influence of the immunosuppressants on the development and course of the experimental candidiasis was studied using the model of the murine vaginitis. As distinct from the mice with an intact immune system in which the fungi penetrate into the mucous membrane epithelium only superficially and are rapidly destroyed by the neutrophil granulocytes, the administration of immunosuppressants results in the penetration of the pseudomycelium through the epithelium and its invasion into the lamina propria, vessels and (in some cases) the development of the hematogenic dissemination. Tissue protective reactions are totally inhibited after the administration of high doses and partly depressed and inefficient after moderate doses of immunosuppressants.
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