Modeling studies suggest that Antarctic ozone depletion and, to a lesser degree, greenhouse gas (GHG) increase have caused the observed poleward shift in the westerly jet during the austral summer. Similar studies have not been performed previously with observational data because of difficulties in separating the two contributions. By applying a cluster analysis to daily ERA-Interim data, we found two 7- to 11-day wind clusters, one resembling the models' responses to GHG forcing and the other resembling ozone depletion. The trends in the clusters' frequency of occurrence indicate that the ozone contributed about 50% more than GHG toward the jet shift, supporting the modeling results. Moreover, tropical convection apparently plays an important role for the GHG-driven trend.
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http://dx.doi.org/10.1126/science.1225154 | DOI Listing |
Am J Manag Care
January 2025
Health Economics Resource Center, VA Palo Alto Health Care System, 795 Willow Rd, Menlo Park, CA 94025. Email:
Objectives: Unused medical appointments affect both patient care and clinic operations, and the frequency of cancellations due to clinic reasons is underreported. The prevalence of these unused appointments in primary care in the Veterans Affairs Health Care System (VA) is unknown. This study examined the prevalence of unused primary care appointments and compared the relative frequency of cancellations and no-shows for patient and clinic reasons.
View Article and Find Full Text PDFBiomol Biomed
January 2025
Department of Otorhinolaryngology and Head and Neck Surgery, The Affiliated Zhuzhou Hospital Xiangya Medical College CSU, Zhuzhou, China.
Diabetes mellitus (DM) has been suggested as a potential risk factor for tinnitus, but evidence remains inconclusive. This meta-analysis aimed to evaluate the association between DM and tinnitus by systematically reviewing and synthesizing data from observational studies. A comprehensive literature search was conducted in PubMed, Embase, and Web of Science up to August 16, 2024.
View Article and Find Full Text PDFScience
January 2025
Australian Antarctic Program Partnership, Institute for Marine and Antarctic Studies, University of Tasmania, nipaluna/Hobart, Tasmania, Australia.
Vertical migrations by marine organisms contribute to carbon export by consumption of surface phytoplankton followed by defecation in the deep ocean. However, biogeochemical models lack observational data, leading to oversimplified representation of carbon cycling by migrating organisms, such as Antarctic krill (). Using a numerical model informed by 1 year of acoustic observations in the East Antarctic, we estimated the total particulate organic carbon (POC) flux from krill fecal pellets to be 9.
View Article and Find Full Text PDFPLOS Digit Health
January 2025
Cancer Registry of Norway, Norwegian Institute of Public health, Ullernchausseen 64, 0379 Oslo, Norway.
An external control arm based on health registry data can serve as an alternative comparator in single-arm drug development studies that lack a benchmark for comparison to the experimental treatment. However, accessing such observational healthcare data involves a lengthy and intricate application process, delaying drug approval studies and access to novel treatments. Clinical trials typically comprise only a few hundred patients usually with high-cardinality features, which makes individual data instances more exposed to re-identification attacks.
View Article and Find Full Text PDFPLoS Med
January 2025
Division of Psychiatry, University College London, London, United Kingdom.
Background: There is limited and conflicting evidence on the comparative cardiometabolic safety and effectiveness of aripiprazole in the management of severe mental illness. We investigated the hypothesis that aripiprazole has a favourable cardiometabolic profile, but similar effectiveness when compared to olanzapine, quetiapine, and risperidone.
Methods And Findings: We conducted an observational emulation of a head-to-head trial of aripiprazole versus olanzapine, quetiapine, and risperidone in UK primary care using data from the Clinical Practice Research Datalink.
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