AI Article Synopsis
- Bacterial sepsis is a severe condition that can cause organ failure and death, even with appropriate antibiotic treatment.
- Researchers have developed a method using magnetic nanoparticles (MNPs) coated with bis-Zn-DPA, which can effectively bind to and remove both Gram-positive and Gram-negative bacteria from the bloodstream.
- In experiments, these MNPs successfully cleared nearly 100% of the Gram-negative bacterium E. coli from bovine blood at high flow rates, suggesting potential applications for treating septic patients in the future.
Article Abstract
Bacterial sepsis is a serious clinical condition that can lead to multiple organ dysfunction and death despite timely treatment with antibiotics and fluid resuscitation. We have developed an approach to clearing bacteria and endotoxin from the bloodstream, using magnetic nanoparticles (MNPs) modified with bis-Zn-DPA, a synthetic ligand that binds to both Gram-positive and Gram-negative bacteria. Magnetic microfluidic devices were used to remove MNPs bound to Escherichia coli , a Gram-negative bacterium commonly implicated in bacterial sepsis, from bovine whole blood at flows as high as 60 mL/h, resulting in almost 100% clearance. Such devices could be adapted to clear bacteria from septicemic patients.
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| http://dx.doi.org/10.1021/nl3047305 | DOI Listing |
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