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| http://dx.doi.org/10.1523/JNEUROSCI.5019-12.2013 | DOI Listing |
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Distinct release properties of glutamate/GABA co-transmission serve as a frequency-dependent filtering of supramammillary inputs.
Elife
December 2024
Graduate School of Brain Science, Doshisha University, Kyoto, Japan.
Glutamate and GABA co-transmitting neurons exist in several brain regions; however, the mechanism by which these two neurotransmitters are co-released from the same synaptic terminals remains unclear. Here, we show that the supramammillary nucleus (SuM) to dentate granule cell synapses, which co-release glutamate and GABA, exhibit differences between glutamate and GABA release properties in paired-pulse ratio, Ca-sensitivity, presynaptic receptor modulation, and Ca channel-vesicle coupling configuration. Moreover, uniquantal synaptic responses show independent glutamatergic and GABAergic responses.
View Article and Find Full Text PDFWidespread co-release of glutamate and GABA throughout the mouse brain.
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November 2024
Vollum Institute, Oregon Health & Science University, Portland, OR, USA.
Several brain neuronal populations transmit both the excitatory and inhibitory neurotransmitters, glutamate, and GABA. However, it remains largely unknown whether these opposing neurotransmitters are co-released simultaneously or are independently transmitted at different times and locations. By recording from acute mouse brain slices, we observed biphasic miniature postsynaptic currents, i.
View Article and Find Full Text PDFOpposing actions of co-released GABA and neurotensin on the activity of preoptic neurons and on body temperature.
Elife
August 2024
Scintillon Institute, San Diego, United States.
Neurotensin (Nts) is a neuropeptide acting as a neuromodulator in the brain. Pharmacological studies have identified Nts as a potent hypothermic agent. The medial preoptic area, a region that plays an important role in the control of thermoregulation, contains a high density of neurotensinergic neurons and Nts receptors.
View Article and Find Full Text PDFCo-release of GABA and ACh from medial olivocochlear neurons fine tunes cochlear efferent inhibition.
bioRxiv
August 2024
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, "Dr. Héctor N. Torres", Consejo Nacional de Investigaciones Científicas y Técnicas, (1428) Ciudad Autónoma de Buenos Aires, Argentina.
During development, inner hair cells (IHCs) in the mammalian cochlea are unresponsive to acoustic stimuli but instead exhibit spontaneous activity. During this same period, neurons originating from the medial olivocochlear complex (MOC) transiently innervate IHCs, regulating their firing pattern which is crucial for the correct development of the auditory pathway. Although the MOC-IHC is a cholinergic synapse, previous evidence indicates the widespread presence of gamma-aminobutyric acid (GABA) signaling markers, including presynaptic GABA receptors (GABAR).
View Article and Find Full Text PDFOpposing actions of co-released GABA and neurotensin on the activity of preoptic neurons and on body temperature.
bioRxiv
April 2024
Scintillon Institute, 6868 Nancy Ridge Drive, San Diego CA 92121.
Neurotensin (Nts) is a neuropeptide acting as a neuromodulator in the brain. Pharmacological studies have identified Nts as a potent hypothermic agent. The medial preoptic area, a region that plays an important role in the control of thermoregulation, contains a high density of neurotensinergic neurons and Nts receptors.
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