[Expression and significance of pericytes and TGF-β in infantile parotid hemangioma].

Purpose: To study the expression and significance of pericytes and TGF-β in infantile parotid hemangioma.

Methods: The expressions of pericytes and TGF-β at protein level were examined in 76 cases of infant parotid hemangioma by strep avidin-biotin complex (SABC) immunohistochemical technique. All statistical analysis were performed using SPSS 13.0 statistical package. The relationship between the expression of pericytes and TGF-β and clinical phase of hemangioma was analyzed by using Chi-square test. Kappa test was used to determine the relationship between pericytes and TGF-β expression.

Results: The rates of positive expression of pericytes were 86.7%(13/15), 45.5%(10/22) and 51.3%(20/39) in early, middle and advanced stage of hemangioma, respectively. The rates of positive expression of TGF-β were 33.3%(5/15), 40.9%(9/22) and 76.9%(30/39) in early, middle and advanced stage of hemangioma, respectively. There was significantly close correlation between the level of pericytes and clinical phase of hemangioma, as well as between TGF-β expression and clinical phase of hemangioma(P<0.05).

Conclusion: Pericytes and TGF-β may significantly contribute to the proliferation of infantile parotid hemangioma.