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Psychosocial and pharmacologic interventions to reduce harmful alcohol use in low- and middle-income countries.
Cochrane Database Syst Rev
May 2023
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Background: Harmful alcohol use is defined as unhealthy alcohol use that results in adverse physical, psychological, social, or societal consequences and is among the leading risk factors for disease, disability and premature mortality globally. The burden of harmful alcohol use is increasing in low- and middle-income countries (LMICs) and there remains a large unmet need for indicated prevention and treatment interventions to reduce harmful alcohol use in these settings. Evidence regarding which interventions are effective and feasible for addressing harmful and other patterns of unhealthy alcohol use in LMICs is limited, which contributes to this gap in services.
View Article and Find Full Text PDFAttaining sinus rhythm mediates improved outcome with early rhythm control therapy of atrial fibrillation: the EAST-AFNET 4 trial.
Eur Heart J
October 2022
Atrial Fibrillation Network (AFNET), Münster, Germany.
Aims: A strategy of systematic, early rhythm control (ERC) improves cardiovascular outcomes in patients with atrial fibrillation (AF). It is not known how this outcome-reducing effect is mediated.
Methods And Results: Using the Early treatment of Atrial Fibrillation for Stroke prevention Trial (EAST-AFNET 4) data set, potential mediators of the effect of ERC were identified in the total study population at 12-month follow up and further interrogated by use of a four-way decomposition of the treatment effect in an exponential model predicting future primary outcome events.
Early Rhythm Control in Patients With Atrial Fibrillation and High Comorbidity Burden.
Circulation
September 2022
Department of Cardiology, University Heart and Vascular Center (A.R., K.B., A.M., P.K.), University Medical Center Hamburg-Eppendorf, Germany.
Background: The randomized EAST-AFNET4 (Early Treatment of Atrial Fibrillation for Stroke Prevention Trial-Atrial Fibrillation Network) demonstrated that early rhythm control (ERC) reduces adverse cardiovascular outcomes in patients with recently diagnosed atrial fibrillation and stroke risk factors. The effectiveness and safety of ERC in patients with multiple cardiovascular comorbidities is not known.
Methods: These prespecified subanalyses of EAST-AFNET4 compared the effectiveness and safety of ERC with usual care (UC) stratified into patients with higher (CHADS-VASc score ≥4) and lower comorbidity burden.
Clinicodemographic profile of syphilis with rising trends at a tertiary care hospital: The tip of the iceberg.
Indian J Sex Transm Dis AIDS
July 2021
Department of Skin and V.D, B.J.G.M.C and Sassoon General Hospital, Pune, Maharashtra, India.
Syphilis, a genito-ulcerative disease caused by the organism subspecies , is renowned for its invasiveness and immune - evasiveness if untreated.Historical reports from the 15 century indicate that syphilis was perceived as a dangerous infection, and a source of public alarm via fear of contagion and dread of its manifestations. It has varied and subtle features that makes clinical diagnosis difficult and leads to many infections being unrecognised.
View Article and Find Full Text PDFMetastatic Breast Cancer, Organotropism and Therapeutics: A Review.
Curr Cancer Drug Targets
January 2022
Centre of Research for Development, University of Kashmir, Srinagar 190006, India.
The final stage of breast cancer involves spreading breast cancer cells to the vital organs like the brain, liver lungs and bones in the process called metastasis. Once the target organ is overtaken by the metastatic breast cancer cells, its usual function is compromised causing organ dysfunction and death. Despite the significant research on breast cancer metastasis, it's still the main culprit of breast cancer-related deaths.
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