Background And Objective: To measure macular choroidal thickness (CT) using spectral-domain optical coherence tomography (OCT) and to investigate the correlation between CT and age, degree of myopia, and history of macular choroidal neovascularization (CNV).
Patients And Methods: A cross-sectional study included 187 highly myopic eyes of 187 patients examined between January and December 2010. The choroid was imaged with spectral-domain OCT by changing the reference position from the vitreous to the choroid. CT was measured from the outer border of the hyperreflective line corresponding to the retinal pigment epithelium to the inner scleral border.
Results: The mean age was 47.21 ± 14.24 years, the mean spherical equivalent refractive error was -13.66 ± 5.77, and the mean subfoveal CT was 100.71 ± 59.98 μm. CT was correlated negatively with age (P < 10(-3)) and refractive error (P < 10(-3)). Forty-two eyes had a history of CNV, the mean CT was 55.45 ± 24.46 μm, and this was significantly thinner than in eyes without CNV (P < 10(-3)).
Conclusion: In highly myopic eyes, the choroid is thin and undergoes further attenuation with age and increasing myopia. In addition, these findings suggest that the choroid may play a role in the pathogenesis of CNV.
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http://dx.doi.org/10.3928/15428877-20121001-02 | DOI Listing |
Int J Surg Case Rep
January 2025
King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia. Electronic address:
Introduction: Implantable collamer lens (ICL) is a posterior chamber phakic intraocular lens. It is usually indicated for high refractive error correction that cannot be treated by laser vision correction due to physical limitations.
Case Presentation: 39 years old male with a past ocular history of keratoconus underwent astigmatic keratotomy followed by crosslinking in both eyes a couple of years later due to signs of corneal ectasia progression.
Purpose: To observe and explore the correlation between visual outcomes and intraocular lens (IOL) stability after tri-focal IOL implantation in eyes with high myopia.
Methods: Patients with highly myopic cataract (axial length > 26 mm) were enrolled in this prospective study. Thirty-one eyes (31 patients) received implantation of a trifocal IOL (AcrySof IQ PanOptix TFNT00).
Purpose: To evaluate residual refractive errors after intraocular lens (IOL) extraction and the safety and effectiveness of refractive correction procedures.
Methods: The eligibility criteria for this systematic review were patients who had undergone cataract or clear lens extraction and had experienced residual refractive error. All study designs were considered for inclusion and non-English publications, non-peer reviewed articles, books, and systematic reviews were excluded.
Clin Ophthalmol
January 2025
Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
Purpose: The factors that contribute to the progression of macular involvement in RRD have not been extensively investigated. The purpose of this study is to evaluate the association between the preoperative characteristics and macular status of the eyes with rhegmatogenous retinal detachment (RRD).
Methods: This is a retrospective cohort study.
Hum Genet
January 2025
Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Refractive error (RE) and myopia are complex polygenic conditions with the majority of genome-wide associated genetic variants in non-exonic regions. Given this, and the onset during childhood, gene-regulation is expected to play an important role in its pathogenesis. This prompted us to explore beyond traditional gene finding approaches.
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