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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827408 | PMC |
| http://dx.doi.org/10.2450/2012.0183-12 | DOI Listing |
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Prevalence of Vitamin D Deficiency With Biochemical Abnormalities in Children Undergoing Vitamin D Testing.
Clin Endocrinol (Oxf)
December 2024
Department of Medicine, University of Auckland, Auckland, New Zealand.
Objective: Vitamin D deficiency (VDD) in children can cause hypocalcaemia and rickets, but the prevalence of these complications and the 25-hydroxyvitamin D (25OHD) concentrations below which they arise is uncertain. We investigated this in children (< 18 years) with 25OHD measurements.
Design, Measurement And Patients: We obtained 25OHD results from the regional laboratory database, alongside albumin-adjusted serum calcium (aCa), parathyroid hormone (PTH) and alkaline phosphatase (ALP) within 6 months of the index 25OHD.
Hepatocellular Carcinoma Developing in a Patient 29 Years After Achieving Sustained Virologic Response for Hepatitis C With Interferon Therapy: A Case Report.
Cureus
November 2024
Department of Radiology, Mito Kyodo General Hospital, Mito, JPN.
We report a case of an 87-year-old female with a ruptured hepatocellular carcinoma (HCC). She presented with sudden epigastric and right upper abdominal pain. The physical examination revealed mild tenderness in the right upper abdomen, a positive Murphy's sign, and no jaundice.
View Article and Find Full Text PDFExploring the relationship between vitamin C deficiency and protein-energy malnutrition in adult hospitalised patients: A cross-sectional study.
Nutr Diet
December 2024
Department of Nutrition, Dietetics and Food, School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Notting Hill, Victoria, Australia.
Aims: To explore the prevalence of vitamin C deficiency, 'undetectable' vitamin C status, and scurvy features, in adult hospitalised patients with protein-energy malnutrition diagnosed using validated malnutrition screening and assessment tools commonly used in clinical practice.
Methods: This study included adult inpatients from four acute hospitals within a single Australian tertiary health service, over a 3.5-year period.
Insights into pharmaceutical co-crystallization using coherent Raman microscopy.
J Pharm Sci
January 2025
Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5E, 00790 Helsinki, Finland. Electronic address:
Article Synopsis
- This study focuses on the process of creating co-crystals of active pharmaceutical ingredients (APIs) and highlights the importance of understanding co-crystallization behaviors under different conditions.
- The researchers utilized two advanced imaging techniques, narrowband CARS and hyperspectral SRS, to observe co-crystallization in real-time, revealing key differences in component identification and overall co-crystal formation.
- The findings provide new insights into the co-crystallization process, including unexpected trace forms and the influence of ethanol content on co-crystal stability during milling.
Ascorbate deficiency increases quiescence and self-renewal in hematopoietic stem cells and multipotent progenitors.
Blood
January 2025
Department of Pediatrics, Children's Research Institute, University of Texas Southwestern Medical Center, Dallas, TX.
Article Synopsis
- Ascorbate (vitamin C) decreases the function of hematopoietic stem cells (HSCs) and helps prevent leukemia by enhancing the activity of the Tet2 tumor suppressor.
- Deleting the Slc23a2 transporter from hematopoietic cells caused a significant drop in ascorbate levels within HSCs and multipotent progenitors (MPPs) but did not affect overall plasma ascorbate levels.
- This deficiency led to increased reconstitution and self-renewal capabilities of HSCs and MPPs when transplanted into irradiated mice, particularly in their quiescent states, indicating that low ascorbate levels may enhance their long-term potential.
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