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| http://dx.doi.org/10.1002/anie.201209222 | DOI Listing |
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Hepatic adverse events associated with ketamine and esketamine: A population-based disproportionality analysis.
J Affect Disord
January 2025
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Electronic address:
Background And Objective: To determine whether there is disproportionate reporting of hepatobiliary disorders in the United States (US) FDA Adverse Event Reporting System (FAERS) for individuals prescribed ketamine or esketamine.
Design: We identified Medical Dictionary for Regulatory Activities (MedDRA) terms in the FAERS related to hepatobiliary disorders.
Main Measures: Formulations of ketamine and esketamine were evaluated for the proportionality of reporting for each hepatobiliary disorder parameter using the reporting odds ratio (ROR).
Mathematical modeling and QSPR analysis of hepatitis treatment drugs through connection indices an innovative approach.
Heliyon
January 2025
Department of Mathematics, Faculty of Sciences, Ghazi University, Dera Ghazi Khan, 32200, Pakistan.
Chemical structures may be defined based on their topology, which allows for the organization of molecules and the representation of new structures with specific properties. We use topological indices, which are precise numerical measurements independent of structure, to measure the bonding arrangement of a chemical network. An essential objective of studying topological indices is to collect and alter chemical structure data to develop a mathematical relationship between structures and physico-chemical properties, bio-activities, and associated experimental factors.
View Article and Find Full Text PDFGenome-Wide Association Study to Identify Genetic Factors Linked to HBV Reactivation Following Liver Transplantation in HBV-Infected Patients.
Int J Mol Sci
December 2024
Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, Republic of Korea.
This study utilized a genome-wide association study (GWAS) to investigate the genetic variations linked to the risk of hepatitis B virus (HBV) reactivation in patients who have undergone liver transplantation (LT), aiming to enhance understanding and improve clinical outcomes. Genotyping performed on a selected patients from the Korean Organ Transplantation Registry (KOTRY) data using high-throughput platforms with the Axiom Korea Biobank array 1.1.
View Article and Find Full Text PDFNovel digital droplet inverse PCR assay shows that natural clearance of hepatitis B infection is associated with fewer viral integrations.
Emerg Microbes Infect
December 2025
Storr Liver Centre, The Westmead Institute for Medical Research, Westmead Hospital and The University of Sydney, Westmead, NSW, Australia.
Hepatitis B virus (HBV) DNA integration into the host cell genome is reportedly a major cause of liver cancer, and a source of hepatitis B surface antigen (HBsAg). High HBsAg levels can alter immune responses which therefore contributes to the progression of HBV-related disease. However, to what extent integration leads to the persistent circulating HBsAg is unclear.
View Article and Find Full Text PDFSustainable integration of artificial intelligence and machine learning approaches within the African infectious disease vaccine research and development ecosystem.
Front Pharmacol
December 2024
Henry Jackson Foundation Medical Research International, Nairobi, Kenya.
Article Synopsis
- AI/ML techniques like reverse vaccinology and predictive models have been successfully used to create vaccine candidates for diseases such as COVID-19, HIV, and Hepatitis, making the vaccine development process faster and more efficient.
- The use of AI and ML in health interventions, including drug discovery and clinical development, is growing in Africa, especially in countries like South Africa, Kenya, and Nigeria.
- To build a sustainable AI/ML ecosystem in Africa, there is a need for more initiatives focused on improving knowledge, enhancing collaboration, establishing strong regulatory and ethical guidelines, and investing in necessary infrastructure.
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